5-[5-(4-Methyl-benzyl)-thiophen-2-yl]-1-[4-(2,3,4-trimethoxy-benzyl)-piperazin-1-yl]-pentan-1-one

Base Information

• Chemical Name: 5-[5-(4-Methyl-benzyl)-thiophen-2-yl]-1-[4-(2,3,4-trimethoxy-benzyl)-piperazin-1-yl]-pentan-1-one
• CAS No.: 1026904-50-6
• Molecular Formula: C₃₁H₄₀N₂O₄S
• Molecular Weight: 536.736
• Mol file: 1026904-50-6.mol

Synonyms:

Chemical Property of 5-[5-(4-Methyl-benzyl)-thiophen-2-yl]-1-[4-(2,3,4-trimethoxy-benzyl)-piperazin-1-yl]-pentan-1-one

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5-[5-(4-Methyl-benzyl)-thiophen-2-yl]-1-[4-(2,3,4-trimethoxy-benzyl)-piperazin-1-yl]-pentan-1-one

There total 5 articles about 5-[5-(4-Methyl-benzyl)-thiophen-2-yl]-1-[4-(2,3,4-trimethoxy-benzyl)-piperazin-1-yl]-pentan-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-thienyl 4-methylphenyl ketone (6933-25-1) → 5-[5-(4-Methyl-benzyl)-thiophen-2-yl]-1-[4-(2,3,4-trimethoxy-benzyl)-piperazin-1-yl]-pentan-1-one (1026904-50-6)

Guidance literature:

Multi-step reaction with 4 steps

1: 1.) NH₂-NH₂, KOH, 2.) aq. HCl / 1.) triethylene glycol, from 96 deg C to 215 deg C, 15 min, 2.) room temp.

2: AlCl₃ / nitrobenzene / 12 h / Ambient temperature

3: 1.) NH₂-NH₂, KOH, 2.) aq. HCl / 1.) triethylene glycol, from 96 deg C to 215 deg C, 30 min, 2.) room temp.

4: 1.) oxalyl chloride / 1.) chloroform, 40 deg C, 30 min., 2.) ethyl ether, 20 deg C, 2 h

With hydrogenchloride; potassium hydroxide; aluminium trichloride; oxalyl dichloride; hydrazine; In nitrobenzene;

Reference yield:

2-[(4-methylphenyl)methyl]thiophene (113386-21-3) → 5-[5-(4-Methyl-benzyl)-thiophen-2-yl]-1-[4-(2,3,4-trimethoxy-benzyl)-piperazin-1-yl]-pentan-1-one (1026904-50-6)

Guidance literature:

Multi-step reaction with 3 steps

1: AlCl₃ / nitrobenzene / 12 h / Ambient temperature

2: 1.) NH₂-NH₂, KOH, 2.) aq. HCl / 1.) triethylene glycol, from 96 deg C to 215 deg C, 30 min, 2.) room temp.

3: 1.) oxalyl chloride / 1.) chloroform, 40 deg C, 30 min., 2.) ethyl ether, 20 deg C, 2 h

With hydrogenchloride; potassium hydroxide; aluminium trichloride; oxalyl dichloride; hydrazine; In nitrobenzene;

Reference yield:

p-Toluic acid (99-94-5) → 5-[5-(4-Methyl-benzyl)-thiophen-2-yl]-1-[4-(2,3,4-trimethoxy-benzyl)-piperazin-1-yl]-pentan-1-one (1026904-50-6)

Guidance literature:

Multi-step reaction with 5 steps

1: 1.) SOCl₂, 2.) SnCl₄ / 1.) 40 deg C, half an h., 2.) methylene chloride, -5 deg C to 5 deg C

2: 1.) NH₂-NH₂, KOH, 2.) aq. HCl / 1.) triethylene glycol, from 96 deg C to 215 deg C, 15 min, 2.) room temp.

3: AlCl₃ / nitrobenzene / 12 h / Ambient temperature

4: 1.) NH₂-NH₂, KOH, 2.) aq. HCl / 1.) triethylene glycol, from 96 deg C to 215 deg C, 30 min, 2.) room temp.

5: 1.) oxalyl chloride / 1.) chloroform, 40 deg C, 30 min., 2.) ethyl ether, 20 deg C, 2 h

With hydrogenchloride; potassium hydroxide; aluminium trichloride; thionyl chloride; oxalyl dichloride; tin(IV) chloride; hydrazine; In nitrobenzene;

upstream raw materials:

1-(2,3,4-trimethoxybenzyl)piperazine

5-[5-(4-Methyl-benzyl)-thiophen-2-yl]-pentanoic acid

2-thienyl 4-methylphenyl ketone

2-[(4-methylphenyl)methyl]thiophene