Pyrimidine-5-carboxylic acid-{1-[4-(4-chloro-2-fluoro-phenoxy)-3-fluoro-benzylcarbamoyl]-cyclopropyl}-amide hydrochloride

Base Information

• Chemical Name: Pyrimidine-5-carboxylic acid-{1-[4-(4-chloro-2-fluoro-phenoxy)-3-fluoro-benzylcarbamoyl]-cyclopropyl}-amide hydrochloride
• CAS No.: 1126633-21-3
• Molecular Formula: C₂₂H₁₇ClF₂N₄O₃*ClH
• Molecular Weight: 495.313
• Mol file: 1126633-21-3.mol

Synonyms:

Chemical Property of Pyrimidine-5-carboxylic acid-{1-[4-(4-chloro-2-fluoro-phenoxy)-3-fluoro-benzylcarbamoyl]-cyclopropyl}-amide hydrochloride

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Pyrimidine-5-carboxylic acid-{1-[4-(4-chloro-2-fluoro-phenoxy)-3-fluoro-benzylcarbamoyl]-cyclopropyl}-amide hydrochloride

There total 5 articles about Pyrimidine-5-carboxylic acid-{1-[4-(4-chloro-2-fluoro-phenoxy)-3-fluoro-benzylcarbamoyl]-cyclopropyl}-amide hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-(4-chloro-2-fluoro-phenoxy)-3-fluoro-benzonitrile (1126633-01-9) → Pyrimidine-5-carboxylic acid-{1-[4-(4-chloro-2-fluoro-phenoxy)-3-fluoro-benzylcarbamoyl]-cyclopropyl}-amide hydrochloride (1126633-21-3)

Guidance literature:

Multi-step reaction with 2 steps

1: hydrogen; ammonia / Raney nickel / methanol / 50 °C / 2585.81 Torr

2: triethylamine; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate / tetrahydrofuran / 20 °C

With ammonia; hydrogen; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine; Raney nickel; In tetrahydrofuran; methanol;

Reference yield:

4-chloro-2-fluorophenol (348-62-9) → Pyrimidine-5-carboxylic acid-{1-[4-(4-chloro-2-fluoro-phenoxy)-3-fluoro-benzylcarbamoyl]-cyclopropyl}-amide hydrochloride (1126633-21-3)

Guidance literature:

Multi-step reaction with 3 steps

1.1: potassium tert-butylate / dimethyl sulfoxide / 1 h / 20 °C

1.2: 60 °C

2.1: hydrogen; ammonia / Raney nickel / methanol / 50 °C / 2585.81 Torr

3.1: triethylamine; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate / tetrahydrofuran / 20 °C

With potassium tert-butylate; ammonia; hydrogen; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine; Raney nickel; In tetrahydrofuran; methanol; dimethyl sulfoxide;

Reference yield:

3,4-Difluorobenzonitrile (64248-62-0) → Pyrimidine-5-carboxylic acid-{1-[4-(4-chloro-2-fluoro-phenoxy)-3-fluoro-benzylcarbamoyl]-cyclopropyl}-amide hydrochloride (1126633-21-3)

Guidance literature:

Multi-step reaction with 3 steps

1.1: potassium tert-butylate / dimethyl sulfoxide / 1 h / 20 °C

1.2: 60 °C

2.1: hydrogen; ammonia / Raney nickel / methanol / 50 °C / 2585.81 Torr

3.1: triethylamine; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate / tetrahydrofuran / 20 °C

With potassium tert-butylate; ammonia; hydrogen; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine; Raney nickel; In tetrahydrofuran; methanol; dimethyl sulfoxide;

upstream raw materials:

pyrimidine-5-carboxylic acid

4-chloro-2-fluorophenol

3,4-Difluorobenzonitrile

ethyl 1-[(pyrimidin-5-ylcarbonyl)amino]-cyclopropanecarboxylate

Refernces