3-methyl-5-<2-chloro-4-(3-hydroxypropyl)phenyl>-8-(3-butynyloxycarbonyl)-6,7,8,9-tetrahydro-1H,3H-pyrido<4',3':4,5>thieno<3,2-f><1,4>-diazepin-2-one

Base Information

Chemical Name:3-methyl-5-<2-chloro-4-(3-hydroxypropyl)phenyl>-8-(3-butynyloxycarbonyl)-6,7,8,9-tetrahydro-1H,3H-pyrido<4',3':4,5>thieno<3,2-f><1,4>-diazepin-2-one
CAS No.:141733-80-4
Molecular Formula:C₂₅H₂₆ClN₃O₄S
Molecular Weight:500.018
Hs Code.:

3-methyl-5-<2-chloro-4-(3-hydroxypropyl)phenyl>-8-(3-butynyloxycarbonyl)-6,7,8,9-tetrahydro-1H,3H-pyrido<4',3':4,5>thieno<3,2-f><1,4>-diazepin-2-one

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Chemical Property of 3-methyl-5-<2-chloro-4-(3-hydroxypropyl)phenyl>-8-(3-butynyloxycarbonyl)-6,7,8,9-tetrahydro-1H,3H-pyrido<4',3':4,5>thieno<3,2-f><1,4>-diazepin-2-one

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Technology Process of 3-methyl-5-<2-chloro-4-(3-hydroxypropyl)phenyl>-8-(3-butynyloxycarbonyl)-6,7,8,9-tetrahydro-1H,3H-pyrido<4',3':4,5>thieno<3,2-f><1,4>-diazepin-2-one

There total 12 articles about 3-methyl-5-<2-chloro-4-(3-hydroxypropyl)phenyl>-8-(3-butynyloxycarbonyl)-6,7,8,9-tetrahydro-1H,3H-pyrido<4',3':4,5>thieno<3,2-f><1,4>-diazepin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 141733-79-1
3-methyl-5-<2-chloro-4-(3-alanyloxypropyl)phenyl>-8-(3-butynyloxycarbonyl)-6,7,8,9-tetrahydro-1H,3H-pyrido<4',3':4,5>thieno<3,2-f><1,4>-diazepin-2-one

: 141733-80-4
3-methyl-5-<2-chloro-4-(3-hydroxypropyl)phenyl>-8-(3-butynyloxycarbonyl)-6,7,8,9-tetrahydro-1H,3H-pyrido<4',3':4,5>thieno<3,2-f><1,4>-diazepin-2-one

Guidance literature:: With sodium hydroxide; In ethanol; for 1.5h; Ambient temperature;
DOI:10.1248/cpb.40.762

Reference yield:

: 5382-16-1
4-HYDROXYPIPERIDINE

: 141733-80-4
3-methyl-5-<2-chloro-4-(3-hydroxypropyl)phenyl>-8-(3-butynyloxycarbonyl)-6,7,8,9-tetrahydro-1H,3H-pyrido<4',3':4,5>thieno<3,2-f><1,4>-diazepin-2-one

Guidance literature:: Multi-step reaction with 6 steps

1: 0.5 h / 110 °C

2: 1.) DMSO, oxalyl chloride, 2.) Et₃N / 1.) CH₂Cl₂, from -70 deg C to -50 deg C, 30 min, 2.) CH₂Cl₂, from -50 deg C to RT

3: 72 percent / Et₃N, sulfur / dimethylformamide / 1 h / 50 °C

4: 247 g / CHCl₃ / Ambient temperature

5: 290 g / pyridine, AcOH / toluene / 1.5 h / Heating

6: 199 g / NaOH / ethanol / 1.5 h / Ambient temperature

With pyridine; sodium hydroxide; oxalyl dichloride; sulfur; acetic acid; dimethyl sulfoxide; triethylamine; In ethanol; chloroform; N,N-dimethyl-formamide; toluene;
DOI:10.1248/cpb.40.762

Reference yield:

: 130312-22-0
3-butyne phenyl carbonate

: 141733-80-4
3-methyl-5-<2-chloro-4-(3-hydroxypropyl)phenyl>-8-(3-butynyloxycarbonyl)-6,7,8,9-tetrahydro-1H,3H-pyrido<4',3':4,5>thieno<3,2-f><1,4>-diazepin-2-one

Guidance literature:: Multi-step reaction with 6 steps

1: 0.5 h / 110 °C

2: 1.) DMSO, oxalyl chloride, 2.) Et₃N / 1.) CH₂Cl₂, from -70 deg C to -50 deg C, 30 min, 2.) CH₂Cl₂, from -50 deg C to RT

3: 72 percent / Et₃N, sulfur / dimethylformamide / 1 h / 50 °C

4: 247 g / CHCl₃ / Ambient temperature

5: 290 g / pyridine, AcOH / toluene / 1.5 h / Heating

6: 199 g / NaOH / ethanol / 1.5 h / Ambient temperature

With pyridine; sodium hydroxide; oxalyl dichloride; sulfur; acetic acid; dimethyl sulfoxide; triethylamine; In ethanol; chloroform; N,N-dimethyl-formamide; toluene;
DOI:10.1248/cpb.40.762