5-methyl-7-(p-tolyl)-1,2,4-triazolo[4''',3''':1'',6'']pyrimido[4'',5'':4',5']thieno[3',2':5,6]pyrido[3,2-c]-cinnolin-3(2H)-thione

Base Information

• Chemical Name: 5-methyl-7-(p-tolyl)-1,2,4-triazolo[4''',3''':1'',6'']pyrimido[4'',5'':4',5']thieno[3',2':5,6]pyrido[3,2-c]-cinnolin-3(2H)-thione
• CAS No.: 212519-74-9
• Molecular Formula: C₂₄H₁₅N₇S₂
• Molecular Weight: 465.562
• Mol file: 212519-74-9.mol

Synonyms:

Chemical Property of 5-methyl-7-(p-tolyl)-1,2,4-triazolo[4''',3''':1'',6'']pyrimido[4'',5'':4',5']thieno[3',2':5,6]pyrido[3,2-c]-cinnolin-3(2H)-thione

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5-methyl-7-(p-tolyl)-1,2,4-triazolo[4''',3''':1'',6'']pyrimido[4'',5'':4',5']thieno[3',2':5,6]pyrido[3,2-c]-cinnolin-3(2H)-thione

There total 12 articles about 5-methyl-7-(p-tolyl)-1,2,4-triazolo[4''',3''':1'',6'']pyrimido[4'',5'':4',5']thieno[3',2':5,6]pyrido[3,2-c]-cinnolin-3(2H)-thione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(4-aminocinnolin-3-yl)-p-tolylmethanone (91913-27-8) → 5-methyl-7-(p-tolyl)-1,2,4-triazolo[4''',3''':1'',6'']pyrimido[4'',5'':4',5']thieno[3',2':5,6]pyrido[3,2-c]-cinnolin-3(2H)-thione (212519-74-9)

Guidance literature:

Multi-step reaction with 10 steps

1: 56 percent / AcONH₄ / 3 h / Heating

2: 86 percent / P₂S₅, pyridine / 4 h / Heating

3: 79 percent / AcONa / ethanol / 1 h / Heating

4: 82 percent / EtONa / ethanol / 0.5 h / Heating

5: 70 percent / EtONa / ethanol / 3 h / Heating

6: 74 percent / 2 h / Heating

7: 80 percent / AcONH₄, AcOH / 0.5 h / Heating

8: 68 percent / POCl₃ / 4 h / Heating

9: 85 percent / NH₂NH₂*H₂O / dioxane / 0.5 h / Heating

10: pyridine / 8 h / Heating

With pyridine; tetraphosphorus decasulfide; ammonium acetate; sodium ethanolate; sodium acetate; hydrazine hydrate; acetic acid; trichlorophosphate; In 1,4-dioxane; ethanol;

DOI:10.1139/v98-048

Reference yield:

toluene (108-88-3,15644-74-3,16713-13-6) → 5-methyl-7-(p-tolyl)-1,2,4-triazolo[4''',3''':1'',6'']pyrimido[4'',5'':4',5']thieno[3',2':5,6]pyrido[3,2-c]-cinnolin-3(2H)-thione (212519-74-9)

Guidance literature:

Multi-step reaction with 11 steps

1: AlCl₃ / 3 h / Heating

2: 56 percent / AcONH₄ / 3 h / Heating

3: 86 percent / P₂S₅, pyridine / 4 h / Heating

4: 79 percent / AcONa / ethanol / 1 h / Heating

5: 82 percent / EtONa / ethanol / 0.5 h / Heating

6: 70 percent / EtONa / ethanol / 3 h / Heating

7: 74 percent / 2 h / Heating

8: 80 percent / AcONH₄, AcOH / 0.5 h / Heating

9: 68 percent / POCl₃ / 4 h / Heating

10: 85 percent / NH₂NH₂*H₂O / dioxane / 0.5 h / Heating

11: pyridine / 8 h / Heating

With pyridine; aluminium trichloride; tetraphosphorus decasulfide; ammonium acetate; sodium ethanolate; sodium acetate; hydrazine hydrate; acetic acid; trichlorophosphate; In 1,4-dioxane; ethanol;

DOI:10.1139/v98-048

Reference yield:

2-phenylhydrazonomalononitrile (306-18-3) → 5-methyl-7-(p-tolyl)-1,2,4-triazolo[4''',3''':1'',6'']pyrimido[4'',5'':4',5']thieno[3',2':5,6]pyrido[3,2-c]-cinnolin-3(2H)-thione (212519-74-9)

Guidance literature:

Multi-step reaction with 11 steps

1: AlCl₃ / 3 h / Heating

2: 56 percent / AcONH₄ / 3 h / Heating

3: 86 percent / P₂S₅, pyridine / 4 h / Heating

4: 79 percent / AcONa / ethanol / 1 h / Heating

5: 82 percent / EtONa / ethanol / 0.5 h / Heating

6: 70 percent / EtONa / ethanol / 3 h / Heating

7: 74 percent / 2 h / Heating

8: 80 percent / AcONH₄, AcOH / 0.5 h / Heating

9: 68 percent / POCl₃ / 4 h / Heating

10: 85 percent / NH₂NH₂*H₂O / dioxane / 0.5 h / Heating

11: pyridine / 8 h / Heating

With pyridine; aluminium trichloride; tetraphosphorus decasulfide; ammonium acetate; sodium ethanolate; sodium acetate; hydrazine hydrate; acetic acid; trichlorophosphate; In 1,4-dioxane; ethanol;

DOI:10.1139/v98-048

upstream raw materials:

carbon disulfide

(9-Methyl-7-p-tolyl-12-thia-5,6,8,10,13-pentaaza-indeno[1,2-b]phenanthren-11-yl)-hydrazine

(4-aminocinnolin-3-yl)-p-tolylmethanone

toluene