C₃₂H₄₉N₃O₇S₃

Base Information

• Chemical Name: C₃₂H₄₉N₃O₇S₃
• CAS No.: 1026614-18-5
• Molecular Formula: C₃₂H₄₉N₃O₇S₃
• Molecular Weight: 683.955
• Mol file: 1026614-18-5.mol

Synonyms:

Chemical Property of C₃₂H₄₉N₃O₇S₃

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₃₂H₄₉N₃O₇S₃

There total 10 articles about C₃₂H₄₉N₃O₇S₃ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-tert-butyl 2-methyl (2S,4R)-4-hydroxy-1,2-pyrrolidinedicarboxylate (74844-91-0) → C32H49N3O7S3 (1026614-18-5)

Guidance literature:

Multi-step reaction with 10 steps

1.1: 100 percent / (COCl)2; DMSO; Et₃N / CH₂Cl₂ / -78 - 0 °C

2.1: LiN[Si(CH₃)3]2 / tetrahydrofuran / -78 °C

2.2: 30 percent / tetrahydrofuran / -78 - 20 °C

3.1: (PhCH₂)(Cl)Pd(PPh₃)2; LiCl; aq. Na₂CO₃ / 1,2-dimethoxy-ethane / 86 °C

4.1: 100 percent / H₂ / 5 percent Pd/C / ethyl acetate

5.1: aq. LiOH / dioxane / 0 - 20 °C

6.1: 94 percent / 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride; HOBt*H₂O; N-methylmorpholine / dimethylformamide

7.1: 100 percent / Et₃SiH / CH₂Cl₂ / 0 °C

8.1: 70 percent / NaI; iPr₂NEt / dimethylsulfoxide

9.1: 100 percent / aq. LiOH / tetrahydrofuran / 0 °C

10.1: aq. AcOH / dimethylformamide / 0 °C

With 4-methyl-morpholine; triethylsilane; lithium hydroxide; oxalyl dichloride; trans benzyl(chloro)bis(triphenylphosphine)palladium(II); hydrogen; sodium carbonate; benzotriazol-1-ol; acetic acid; dimethyl sulfoxide; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; N-ethyl-N,N-diisopropylamine; sodium iodide; lithium chloride; lithium hexamethyldisilazane; palladium on activated charcoal; In tetrahydrofuran; 1,4-dioxane; 1,2-dimethoxyethane; dichloromethane; dimethyl sulfoxide; ethyl acetate; N,N-dimethyl-formamide; 1.1: Oxidation / 2.1: Enolization / 2.2: Triflation / 3.1: Arylation / 4.1: Catalytic hydrogenation / 5.1: Hydrolysis / 6.1: Acylation / 7.1: Acidolysis / 8.1: Alkylation / 9.1: Hydrolysis / 10.1: Thioacylation;

DOI:10.1248/cpb.48.740

Reference yield:

(S)-1-tert-butyl 2-methyl 4-oxopyrrolidine-1,2-dicarboxylate (102195-80-2) → C32H49N3O7S3 (1026614-18-5)

Guidance literature:

Multi-step reaction with 9 steps

1.1: LiN[Si(CH₃)3]2 / tetrahydrofuran / -78 °C

1.2: 30 percent / tetrahydrofuran / -78 - 20 °C

2.1: (PhCH₂)(Cl)Pd(PPh₃)2; LiCl; aq. Na₂CO₃ / 1,2-dimethoxy-ethane / 86 °C

3.1: 100 percent / H₂ / 5 percent Pd/C / ethyl acetate

4.1: aq. LiOH / dioxane / 0 - 20 °C

5.1: 94 percent / 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride; HOBt*H₂O; N-methylmorpholine / dimethylformamide

6.1: 100 percent / Et₃SiH / CH₂Cl₂ / 0 °C

7.1: 70 percent / NaI; iPr₂NEt / dimethylsulfoxide

8.1: 100 percent / aq. LiOH / tetrahydrofuran / 0 °C

9.1: aq. AcOH / dimethylformamide / 0 °C

With 4-methyl-morpholine; triethylsilane; lithium hydroxide; trans benzyl(chloro)bis(triphenylphosphine)palladium(II); hydrogen; sodium carbonate; benzotriazol-1-ol; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; sodium iodide; lithium chloride; lithium hexamethyldisilazane; palladium on activated charcoal; In tetrahydrofuran; 1,4-dioxane; 1,2-dimethoxyethane; dichloromethane; dimethyl sulfoxide; ethyl acetate; N,N-dimethyl-formamide; 1.1: Enolization / 1.2: Triflation / 2.1: Arylation / 3.1: Catalytic hydrogenation / 4.1: Hydrolysis / 5.1: Acylation / 6.1: Acidolysis / 7.1: Alkylation / 8.1: Hydrolysis / 9.1: Thioacylation;

DOI:10.1248/cpb.48.740

Reference yield:

1-tert-butyl 2-methyl (2S)-4-(trifluoromethanesulfonyloxy)-2,3-dihydropyrrole-1,2-dicarboxylate (284047-10-5) → C32H49N3O7S3 (1026614-18-5)

Guidance literature:

Multi-step reaction with 8 steps

1: (PhCH₂)(Cl)Pd(PPh₃)2; LiCl; aq. Na₂CO₃ / 1,2-dimethoxy-ethane / 86 °C

2: 100 percent / H₂ / 5 percent Pd/C / ethyl acetate

3: aq. LiOH / dioxane / 0 - 20 °C

4: 94 percent / 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride; HOBt*H₂O; N-methylmorpholine / dimethylformamide

5: 100 percent / Et₃SiH / CH₂Cl₂ / 0 °C

6: 70 percent / NaI; iPr₂NEt / dimethylsulfoxide

7: 100 percent / aq. LiOH / tetrahydrofuran / 0 °C

8: aq. AcOH / dimethylformamide / 0 °C

With 4-methyl-morpholine; triethylsilane; lithium hydroxide; trans benzyl(chloro)bis(triphenylphosphine)palladium(II); hydrogen; sodium carbonate; benzotriazol-1-ol; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; sodium iodide; lithium chloride; palladium on activated charcoal; In tetrahydrofuran; 1,4-dioxane; 1,2-dimethoxyethane; dichloromethane; dimethyl sulfoxide; ethyl acetate; N,N-dimethyl-formamide; 1: Arylation / 2: Catalytic hydrogenation / 3: Hydrolysis / 4: Acylation / 5: Acidolysis / 6: Alkylation / 7: Hydrolysis / 8: Thioacylation;

DOI:10.1248/cpb.48.740

upstream raw materials:

metgoxycarbonylsulfenyl chloride

1-tert-butyl 2-methyl (2S,4R)-4-hydroxy-1,2-pyrrolidinedicarboxylate

(S)-1-tert-butyl 2-methyl 4-oxopyrrolidine-1,2-dicarboxylate

1-tert-butyl 2-methyl (2S)-4-(trifluoromethanesulfonyloxy)-2,3-dihydropyrrole-1,2-dicarboxylate