(R)-4-((2-(3-(2-fluoro-6-(trifluoromethyl)benzyl)-4-methyl-2,6-dioxo-5-(4-((5-(trifluoromethyl)furan-2-yl)methyl)piperazin-1-yl)-2,3-dihydropyrimidin-1(6H)-yl)-1-phenylethyl)amino)butanoic acid

Base Information

Chemical Name:(R)-4-((2-(3-(2-fluoro-6-(trifluoromethyl)benzyl)-4-methyl-2,6-dioxo-5-(4-((5-(trifluoromethyl)furan-2-yl)methyl)piperazin-1-yl)-2,3-dihydropyrimidin-1(6H)-yl)-1-phenylethyl)amino)butanoic acid
CAS No.:1308378-95-1
Molecular Formula:C₃₅H₃₆F₇N₅O₅
Molecular Weight:739.69
Hs Code.:

(R)-4-((2-(3-(2-fluoro-6-(trifluoromethyl)benzyl)-4-methyl-2,6-dioxo-5-(4-((5-(trifluoromethyl)furan-2-yl)methyl)piperazin-1-yl)-2,3-dihydropyrimidin-1(6H)-yl)-1-phenylethyl)amino)butanoic acid

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Chemical Property of (R)-4-((2-(3-(2-fluoro-6-(trifluoromethyl)benzyl)-4-methyl-2,6-dioxo-5-(4-((5-(trifluoromethyl)furan-2-yl)methyl)piperazin-1-yl)-2,3-dihydropyrimidin-1(6H)-yl)-1-phenylethyl)amino)butanoic acid

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Technology Process of (R)-4-((2-(3-(2-fluoro-6-(trifluoromethyl)benzyl)-4-methyl-2,6-dioxo-5-(4-((5-(trifluoromethyl)furan-2-yl)methyl)piperazin-1-yl)-2,3-dihydropyrimidin-1(6H)-yl)-1-phenylethyl)amino)butanoic acid

There total 7 articles about (R)-4-((2-(3-(2-fluoro-6-(trifluoromethyl)benzyl)-4-methyl-2,6-dioxo-5-(4-((5-(trifluoromethyl)furan-2-yl)methyl)piperazin-1-yl)-2,3-dihydropyrimidin-1(6H)-yl)-1-phenylethyl)amino)butanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₃₇H₄₀F₇N₅O₅

: 1308378-95-1
(R)-4-((2-(3-(2-fluoro-6-(trifluoromethyl)benzyl)-4-methyl-2,6-dioxo-5-(4-((5-(trifluoromethyl)furan-2-yl)methyl)piperazin-1-yl)-2,3-dihydropyrimidin-1(6H)-yl)-1-phenylethyl)amino)butanoic acid

Guidance literature:: C₃₇H₄₀F₇N₅O₅; With sodium hydroxide; In ethanol; water; at 60 ℃; for 3h;

With hydrogenchloride; In water;
DOI:10.1021/acs.jmedchem.6b01071

Reference yield:

: 1308376-62-6
(R)-3-(2-amino-2-phenylethyl)-1-(2-fluoro-6-(trifluoromethyl)benzyl)-6-methyl-5-(4-((5-(trifluoromethyl)furan-2-yl)methyl)piperazin-1-yl)pyrimidine-2,4(1H,3H)-dione

: 1308378-95-1
(R)-4-((2-(3-(2-fluoro-6-(trifluoromethyl)benzyl)-4-methyl-2,6-dioxo-5-(4-((5-(trifluoromethyl)furan-2-yl)methyl)piperazin-1-yl)-2,3-dihydropyrimidin-1(6H)-yl)-1-phenylethyl)amino)butanoic acid

Guidance literature:: Multi-step reaction with 2 steps

1: N-ethyl-N,N-diisopropylamine / acetonitrile / 12 h / 95 °C

2: sodium hydroxide / water; ethanol / 3 h / 60 °C

With N-ethyl-N,N-diisopropylamine; sodium hydroxide; In ethanol; water; acetonitrile;
DOI:10.1021/acs.jmedchem.6b01071

Reference yield:

: 1308380-26-8
((R)-2-{3-(2-fluoro-6-trifluoromethyl-benzyl)-4-methyl-2,6-dioxo-5-[4-(5-trifluoromethyl-furan-2-ylmethyl)-piperazin-1-yl]-3,6-dihydro-2H-pyrimidin-1-yl}-1-phenyl-ethyl)-carbamic acid tert-butyl ester

: 1308378-95-1
(R)-4-((2-(3-(2-fluoro-6-(trifluoromethyl)benzyl)-4-methyl-2,6-dioxo-5-(4-((5-(trifluoromethyl)furan-2-yl)methyl)piperazin-1-yl)-2,3-dihydropyrimidin-1(6H)-yl)-1-phenylethyl)amino)butanoic acid

Guidance literature:: Multi-step reaction with 3 steps

1: trifluoroacetic acid / dichloromethane / 3 h / 0 - 20 °C

2: N-ethyl-N,N-diisopropylamine / acetonitrile / 12 h / 95 °C

3: sodium hydroxide / water; ethanol / 3 h / 60 °C

With N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; sodium hydroxide; In ethanol; dichloromethane; water; acetonitrile;
DOI:10.1021/acs.jmedchem.6b01071