4-benzoyl-N-(6-oxo-6-(6-(5-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanamido)-hexylamino)-5-(4-sulfamoylbenzamido)hexyl)benzamide

Base Information

• Chemical Name: 4-benzoyl-N-(6-oxo-6-(6-(5-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanamido)-hexylamino)-5-(4-sulfamoylbenzamido)hexyl)benzamide
• CAS No.: 1383564-32-6
• Molecular Formula: C₄₃H₅₅N₇O₈S₂
• Molecular Weight: 862.084
• Mol file: 1383564-32-6.mol

Synonyms:

Chemical Property of 4-benzoyl-N-(6-oxo-6-(6-(5-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanamido)-hexylamino)-5-(4-sulfamoylbenzamido)hexyl)benzamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-benzoyl-N-(6-oxo-6-(6-(5-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanamido)-hexylamino)-5-(4-sulfamoylbenzamido)hexyl)benzamide

There total 10 articles about 4-benzoyl-N-(6-oxo-6-(6-(5-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanamido)-hexylamino)-5-(4-sulfamoylbenzamido)hexyl)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C36H50N6O5S + 4-uulfamoyl-benzoic acid 2,5-dioxo-pyrrolidin-1-yl ester (154715-61-4) → 4-benzoyl-N-(6-oxo-6-(6-(5-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanamido)-hexylamino)-5-(4-sulfamoylbenzamido)hexyl)benzamide (1383564-32-6)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 0 - 20 ℃; for 4h;

DOI:10.1002/asia.201200085

Reference yield:

4-(aminosulfonyl)-benzoic acid (138-41-0) → 4-benzoyl-N-(6-oxo-6-(6-(5-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanamido)-hexylamino)-5-(4-sulfamoylbenzamido)hexyl)benzamide (1383564-32-6)

Guidance literature:

Multi-step reaction with 2 steps

1: dicyclohexyl-carbodiimide / N,N-dimethyl-formamide / 21 h / -20 °C

2: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 4 h / 0 - 20 °C

With N-ethyl-N,N-diisopropylamine; dicyclohexyl-carbodiimide; In N,N-dimethyl-formamide;

DOI:10.1002/asia.201200085

Reference yield:

tert-butyl N-(6-aminohexyl)carbamate (51857-17-1) → 4-benzoyl-N-(6-oxo-6-(6-(5-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanamido)-hexylamino)-5-(4-sulfamoylbenzamido)hexyl)benzamide (1383564-32-6)

Guidance literature:

Multi-step reaction with 5 steps

1: DMT-MM / methanol / 20 h

2: hydrogenchloride / 1,4-dioxane; dichloromethane / 1 h / 0 - 20 °C

3: O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 16 h / 0 - 20 °C

4: hydrogenchloride / 1,4-dioxane / 1 h / 0 - 20 °C

5: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 4 h / 0 - 20 °C

With hydrogenchloride; DMT-MM; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In 1,4-dioxane; methanol; dichloromethane; N,N-dimethyl-formamide;

DOI:10.1002/asia.201200085

upstream raw materials:

4-uulfamoyl-benzoic acid 2,5-dioxo-pyrrolidin-1-yl ester

tert-butyl-6-(4-benzoylbenzamido)-1-oxo-1-(6-(5-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)-pentanamido)hexylamino)hexan-2-ylcarbamate

4-(aminosulfonyl)-benzoic acid

4-carboxybenzophenone