3-(6-chloropyridin-3-yl)-2-(2-methoxyphenyl)-5-[(1-methylethyl)sulfonyl]-2,4,5,6-tetrahydropyrrolo[3,4-c]pyrazole

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Chemical Name:3-(6-chloropyridin-3-yl)-2-(2-methoxyphenyl)-5-[(1-methylethyl)sulfonyl]-2,4,5,6-tetrahydropyrrolo[3,4-c]pyrazole
CAS No.:1567373-32-3
Molecular Formula:C₂₀H₂₁ClN₄O₃S
Molecular Weight:432.931
Hs Code.:

Synonyms:

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Chemical Property of 3-(6-chloropyridin-3-yl)-2-(2-methoxyphenyl)-5-[(1-methylethyl)sulfonyl]-2,4,5,6-tetrahydropyrrolo[3,4-c]pyrazole

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Technology Process of 3-(6-chloropyridin-3-yl)-2-(2-methoxyphenyl)-5-[(1-methylethyl)sulfonyl]-2,4,5,6-tetrahydropyrrolo[3,4-c]pyrazole

There total 6 articles about 3-(6-chloropyridin-3-yl)-2-(2-methoxyphenyl)-5-[(1-methylethyl)sulfonyl]-2,4,5,6-tetrahydropyrrolo[3,4-c]pyrazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1567373-46-9
t-butyl 3-bromo-2-(2-methoxyphenyl)-4,6-dihydropyrrolo[3,4-c]pyrazole-5(2H)-carboxylate

: 1567373-32-3
3-(6-chloropyridin-3-yl)-2-(2-methoxyphenyl)-5-[(1-methylethyl)sulfonyl]-2,4,5,6-tetrahydropyrrolo[3,4-c]pyrazole

Guidance literature:: Multi-step reaction with 3 steps

1: trifluoroacetic acid / dichloromethane / 3 h

2: N-ethyl-N,N-diisopropylamine / dichloromethane / 20 °C

3: sodium carbonate; palladium diacetate; tris-(o-tolyl)phosphine / 1,2-dimethoxyethane / 0.25 h / 80 °C

With palladium diacetate; sodium carbonate; N-ethyl-N,N-diisopropylamine; tris-(o-tolyl)phosphine; trifluoroacetic acid; In 1,2-dimethoxyethane; dichloromethane;

Reference yield:

: 158979-29-4
2-((tert-butoxycarbonyl)(prop-2-yn-1-yl)-amino)acetic acid

: 1567373-32-3
3-(6-chloropyridin-3-yl)-2-(2-methoxyphenyl)-5-[(1-methylethyl)sulfonyl]-2,4,5,6-tetrahydropyrrolo[3,4-c]pyrazole

Guidance literature:: Multi-step reaction with 7 steps

1.1: potassium hydroxide; bromine / water; methanol / 1 h / 0 °C

2.1: 4-methyl-morpholine; isobutyl chloroformate / tetrahydrofuran / 0.5 h / 20 °C / Inert atmosphere

2.2: 1 h

3.1: triphenylphosphine; tetrachloromethane / acetonitrile / 2 h / 20 °C

4.1: triethylamine / toluene / 3 h / 110 °C

5.1: trifluoroacetic acid / dichloromethane / 3 h

6.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 20 °C

7.1: sodium carbonate; palladium diacetate; tris-(o-tolyl)phosphine / 1,2-dimethoxyethane / 0.25 h / 80 °C

With 4-methyl-morpholine; tetrachloromethane; bromine; palladium diacetate; sodium carbonate; triethylamine; N-ethyl-N,N-diisopropylamine; triphenylphosphine; tris-(o-tolyl)phosphine; trifluoroacetic acid; potassium hydroxide; isobutyl chloroformate; In tetrahydrofuran; methanol; 1,2-dimethoxyethane; dichloromethane; water; toluene; acetonitrile;

Reference yield:

: 1567373-47-0
3-bromo-2-(2-methoxyphenyl)-2,4,5,6-tetrahydropyrrolo[3,4-c]pyrazole

: 1567373-32-3
3-(6-chloropyridin-3-yl)-2-(2-methoxyphenyl)-5-[(1-methylethyl)sulfonyl]-2,4,5,6-tetrahydropyrrolo[3,4-c]pyrazole

Guidance literature:: Multi-step reaction with 2 steps

1: N-ethyl-N,N-diisopropylamine / dichloromethane / 20 °C

2: sodium carbonate; palladium diacetate; tris-(o-tolyl)phosphine / 1,2-dimethoxyethane / 0.25 h / 80 °C

With palladium diacetate; sodium carbonate; N-ethyl-N,N-diisopropylamine; tris-(o-tolyl)phosphine; In 1,2-dimethoxyethane; dichloromethane;