1-(4-Aminobutyl)-4-(diphenylmethyl)piperazine

Base Information

• Chemical Name: 1-(4-Aminobutyl)-4-(diphenylmethyl)piperazine
• CAS No.: 101620-10-4
• Molecular Formula: C21H29N3
• Molecular Weight: 323.481
• DSSTox Substance ID: DTXSID30553291
• Wikidata: Q82433840
• Mol file: 101620-10-4.mol

Synonyms:1-(4-Aminobutyl)-4-(diphenylmethyl)piperazine;101620-10-4;4-(4-benzhydrylpiperazin-1-yl)butan-1-amine;4-[4-(Diphenylmethyl)piperazin-1-yl]butan-1-amine;SCHEMBL3631349;DTXSID30553291;NSMZTYPXRYZENQ-UHFFFAOYSA-N;1-(4-aminobutyl)-4-diphenylmethylpiperazine;4-(4-diphenylmethyl-1-piperazinyl)butylamine

Chemical Property of 1-(4-Aminobutyl)-4-(diphenylmethyl)piperazine

Chemical Property:

• XLogP3: 3
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 7
• Exact Mass: 323.236147938
• Heavy Atom Count: 24
• Complexity: 308

Purity/Quality:

98%min ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1CN(CCN1CCCCN)C(C2=CC=CC=C2)C3=CC=CC=C3

Technology Process of 1-(4-Aminobutyl)-4-(diphenylmethyl)piperazine

There total 5 articles about 1-(4-Aminobutyl)-4-(diphenylmethyl)piperazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

N-{4-[4-(diphenylmethyl)piperazin-1-yl]butyl}isoindoline-1,3-dione (101620-09-1) → 4-(4-diphenyl-methyl-1-piperazinyl)butylamine (101620-10-4)

Guidance literature:

With hydrazine hydrate; In ethanol; for 2h; Heating;

DOI:10.1248/cpb.37.100

Reference yield:

C21H25N3 → 4-(4-diphenyl-methyl-1-piperazinyl)butylamine (101620-10-4)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; at 0 - 20 ℃; Inert atmosphere;

DOI:10.1016/j.bmc.2014.12.057

Reference yield:

diphenylmethylpiperazine (841-77-0) → 4-(4-diphenyl-methyl-1-piperazinyl)butylamine (101620-10-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 74 percent / K₂CO₃, NaI / butan-2-one / 4.5 h / Heating

2: 88 percent / hydrazine hydrate / ethanol / 2 h / Heating

With potassium carbonate; hydrazine hydrate; sodium iodide; In ethanol; butanone;

DOI:10.1248/cpb.37.100

upstream raw materials:

N-{4-[4-(diphenylmethyl)piperazin-1-yl]butyl}isoindoline-1,3-dione

4-Chlorobutyronitrile

diphenylmethylpiperazine

Downstream raw materials:

N-[3-(pyridin-3-yl)propionyl]-4-(4-diphenylmethyl-1-piperazinyl)butylamine

Quinoline-3-carboxylic acid [4-(4-benzhydryl-piperazin-1-yl)-butyl]-amide

N-<4-(4-diphenylmethyl-1-piperazinyl)butyl>1,4-dihydro-7-methyl-4-oxo-1,8-naphthyridine-3-carboxamide

N-<4-(4-diphenylmethyl-1-piperazinyl)butyl>-1,4-dihydro-1-methyl-4-oxoquinoline-3-carboxamide