(R)-1-Phenyl-2-(<(tert-butyl)diphenylsilyl>oxy)ethyl (2'S,3R)-2-Methyl-1'-(4-toluenesulfonyl)spiro<3H-indole-3,3'-pyrrolidine>-2'-carboxylate

Base Information

Chemical Name:(R)-1-Phenyl-2-(<(tert-butyl)diphenylsilyl>oxy)ethyl (2'S,3R)-2-Methyl-1'-(4-toluenesulfonyl)spiro<3H-indole-3,3'-pyrrolidine>-2'-carboxylate
CAS No.:129376-69-8
Molecular Formula:C₄₄H₄₆N₂O₅SSi
Molecular Weight:743.011
Hs Code.:

(R)-1-Phenyl-2-(<(tert-butyl)diphenylsilyl>oxy)ethyl (2'S,3R)-2-Methyl-1'-(4-toluenesulfonyl)spiro<3H-indole-3,3'-pyrrolidine>-2'-carboxylate

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Chemical Property of (R)-1-Phenyl-2-(<(tert-butyl)diphenylsilyl>oxy)ethyl (2'S,3R)-2-Methyl-1'-(4-toluenesulfonyl)spiro<3H-indole-3,3'-pyrrolidine>-2'-carboxylate

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Technology Process of (R)-1-Phenyl-2-(<(tert-butyl)diphenylsilyl>oxy)ethyl (2'S,3R)-2-Methyl-1'-(4-toluenesulfonyl)spiro<3H-indole-3,3'-pyrrolidine>-2'-carboxylate

There total 20 articles about (R)-1-Phenyl-2-(<(tert-butyl)diphenylsilyl>oxy)ethyl (2'S,3R)-2-Methyl-1'-(4-toluenesulfonyl)spiro<3H-indole-3,3'-pyrrolidine>-2'-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 95-20-5
2-methyl-1H-indole

: 129376-69-8,129444-90-2
(R)-1-Phenyl-2-(<(tert-butyl)diphenylsilyl>oxy)ethyl (2'R,3S)-2-Methyl-1'-(4-toluenesulfonyl)spiro<3H-indole-3,3'-pyrrolidine>-2'-carboxylate

Guidance literature:: Multi-step reaction with 5 steps

1: 80.4 percent / CF₃COOH / CH₂Cl₂ / 1) 0 deg C, 2.5 h, 2) rt, 20 h

2: 94.5 percent / H₂ / tris(triphenylphosphine)rhodium(I) chloride / benzene / 20 h / 50 °C / 7500.6 Torr

3: H₂ / Pd/C / methanol / 0.5 h / Ambient temperature

4: molecular sieves / CH₂Cl₂ / 0 °C

5: 2,4,6-Trimethylpyridine / CH₂Cl₂ / 16 h / 0 °C

With 2,4,6-trimethyl-pyridine; molecular sieve; hydrogen; trifluoroacetic acid; palladium on activated charcoal; Wilkinson's catalyst; In methanol; dichloromethane; benzene;
DOI:10.1002/hlca.19900730224

Reference yield:

: 95-20-5
2-methyl-1H-indole

: 129376-69-8,129444-90-2
(R)-1-Phenyl-2-(<(tert-butyl)diphenylsilyl>oxy)ethyl (2'S,3R)-2-Methyl-1'-(4-toluenesulfonyl)spiro<3H-indole-3,3'-pyrrolidine>-2'-carboxylate

Guidance literature:: Multi-step reaction with 5 steps

1: 80.4 percent / CF₃COOH / CH₂Cl₂ / 1) 0 deg C, 2.5 h, 2) rt, 20 h

2: 94.5 percent / H₂ / tris(triphenylphosphine)rhodium(I) chloride / benzene / 20 h / 50 °C / 7500.6 Torr

3: H₂ / Pd/C / methanol / 0.5 h / Ambient temperature

4: molecular sieves / CH₂Cl₂ / 0 °C

5: 2,4,6-Trimethylpyridine / CH₂Cl₂ / 16 h / 0 °C

With 2,4,6-trimethyl-pyridine; molecular sieve; hydrogen; trifluoroacetic acid; palladium on activated charcoal; Wilkinson's catalyst; In methanol; dichloromethane; benzene;
DOI:10.1002/hlca.19900730224

Reference yield:

: 104296-24-4
2-Methyl-3-(2-nitroethyl)-1H-indole

: 129376-69-8,129444-90-2
(R)-1-Phenyl-2-(<(tert-butyl)diphenylsilyl>oxy)ethyl (2'R,3S)-2-Methyl-1'-(4-toluenesulfonyl)spiro<3H-indole-3,3'-pyrrolidine>-2'-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: H₂ / Pd/C / methanol / 0.5 h / Ambient temperature

2: molecular sieves / CH₂Cl₂ / 0 °C

3: 2,4,6-Trimethylpyridine / CH₂Cl₂ / 16 h / 0 °C

With 2,4,6-trimethyl-pyridine; molecular sieve; hydrogen; palladium on activated charcoal; In methanol; dichloromethane;
DOI:10.1002/hlca.19900730224