Technology Process of (4R*,4aR*,8aR*)-8a-hydroxy-1-methylene-4-(phenylsulfonyl)decahydronaphthalene
There total 16 articles about (4R*,4aR*,8aR*)-8a-hydroxy-1-methylene-4-(phenylsulfonyl)decahydronaphthalene which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 3-chloroperoxybenzoic acid / CH2Cl2 / 1) 0 deg C, 10 min, 2) r.t., 1 h
2: 30percent H2O2, KOH / ethanol / 6 h / Ambient temperature
3: 90 percent / tetrahydrofuran / 0.5 h / Ambient temperature
4: LDA / tetrahydrofuran / 1) -60 deg C, 10 min, 2) 0 deg C, 1 h, 3) r.t., 10 min
With
potassium hydroxide; dihydrogen peroxide; 3-chloro-benzenecarboperoxoic acid; lithium diisopropyl amide;
In
tetrahydrofuran; ethanol; dichloromethane;
DOI:10.1021/jo00299a052
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 3-chloroperoxybenzoic acid / CH2Cl2 / 1) 0 deg C, 10 min, 2) r.t., 1 h
2: 30percent H2O2, KOH / ethanol / 6 h / Ambient temperature
3: 90 percent / tetrahydrofuran / 0.5 h / Ambient temperature
4: LDA / tetrahydrofuran / 1) -60 deg C, 10 min, 2) 0 deg C, 1 h, 3) r.t., 10 min
With
potassium hydroxide; dihydrogen peroxide; 3-chloro-benzenecarboperoxoic acid; lithium diisopropyl amide;
In
tetrahydrofuran; ethanol; dichloromethane;
DOI:10.1021/jo00299a052
- Guidance literature:
-
Multi-step reaction with 7 steps
1: 1) LDA / THF, - 60 deg C, 1) 15 min, 2) 5 min
2: t-BuOK / 2-methyl-propan-2-ol; tetrahydrofuran / 0.17 h / Ambient temperature
3: 94 percent / LiClO4*3H2O, Bu3PO / toluene / 4.5 h / Heating
4: 3-chloroperoxybenzoic acid / CH2Cl2 / 1) 0 deg C, 10 min, 2) r.t., 1 h
5: 30percent H2O2, KOH / ethanol / 6 h / Ambient temperature
6: 90 percent / tetrahydrofuran / 0.5 h / Ambient temperature
7: LDA / tetrahydrofuran / 1) -60 deg C, 10 min, 2) 0 deg C, 1 h, 3) r.t., 10 min
With
potassium hydroxide; Tributylphosphine oxide; potassium tert-butylate; dihydrogen peroxide; lithium perchlorate; 3-chloro-benzenecarboperoxoic acid; lithium diisopropyl amide;
In
tetrahydrofuran; ethanol; dichloromethane; toluene; tert-butyl alcohol;
DOI:10.1021/jo00299a052
