4-(2-Bromophenyl)pyridine

Base Information

• Chemical Name: 4-(2-Bromophenyl)pyridine
• CAS No.: 101681-34-9
• Molecular Formula: C11H8BrN
• Molecular Weight: 234.095
• European Community (EC) Number: 834-347-1
• Nikkaji Number: J1.803.552I
• Mol file: 101681-34-9.mol

Synonyms:4-(2-bromophenyl)pyridine;101681-34-9;SCHEMBL2331272;BEA68134;MFCD18415515;SB55283;DB-094397;B5153;T70014

Chemical Property of 4-(2-Bromophenyl)pyridine

Chemical Property:

• Melting Point: 62.0 to 66.0 °C
• Boiling Point: 89°C/0.03mmHg(lit.)
• PSA: 12.89000
• LogP: 3.51110
• XLogP3: 3.5
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 1
• Exact Mass: 232.98401
• Heavy Atom Count: 13
• Complexity: 154

Purity/Quality:

97% ^*data from raw suppliers

4-(2-Bromophenyl)pyridine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C(C(=C1)C2=CC=NC=C2)Br

Technology Process of 4-(2-Bromophenyl)pyridine

There total 4 articles about 4-(2-Bromophenyl)pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

2-bromo-1-chlorobenzene (694-80-4) + 4-pyridylboronic acid (1692-15-5) → 4-(2'-bromophenyl)pyridine (101681-34-9)

Guidance literature:

With tetra-butylammonium acetate; Pd EnCat-30^TM; In ethanol; at 120 ℃; for 0.166667h; microwave irradiation;

DOI:10.1002/chem.200501400

Reference yield: 39.0%

4-pyridylboronic acid (1692-15-5) + 2,3-dibromobenzene (583-53-9) → 4-(2'-bromophenyl)pyridine (101681-34-9)

Guidance literature:

With potassium phosphate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In N,N-dimethyl-formamide; at 90 ℃; for 16h;

DOI:10.1002/chem.202103136

Reference yield: 32.0%

1-Bromo-2-iodobenzene (583-55-1) + 4-pyridylboronic acid (1692-15-5) → 4-(2'-bromophenyl)pyridine (101681-34-9)

Guidance literature:

With sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In ethanol; toluene; Heating;

DOI:10.1021/ol026426v

upstream raw materials:

1-Bromo-2-iodobenzene

4-pyridylboronic acid

2-bromo-1-chlorobenzene

2,3-dibromobenzene

Downstream raw materials:

4-(4-bromophenyl)pyridine

N-(9H-indeno[2,1-c]pyridin-9-ylidene)-2,6-diisopropylaniline

2-Azafluoren