1-(3,4-dimethoxyphenyl)-4-imino>cyclohexanecarbonitrile

Base Information

• Chemical Name: 1-(3,4-dimethoxyphenyl)-4-imino>cyclohexanecarbonitrile
• CAS No.: 133648-61-0
• Molecular Formula: C₂₅H₃₀N₂O₄
• Molecular Weight: 422.524
• Mol file: 133648-61-0.mol

Synonyms:

Chemical Property of 1-(3,4-dimethoxyphenyl)-4-imino>cyclohexanecarbonitrile

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-(3,4-dimethoxyphenyl)-4-imino>cyclohexanecarbonitrile

There total 2 articles about 1-(3,4-dimethoxyphenyl)-4-imino>cyclohexanecarbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

methyl 5-cyano-5-(3,4-dimethoxyphenyl)-2-oxocyclohexanecarboxylate (133648-53-0) → 1-(3,4-dimethoxyphenyl)-4-imino>cyclohexanecarbonitrile (133648-61-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 66 percent / acetic acid, 10percent sulfuric acid / 5 h / Heating

2: p-toluenesulfonic acid monohydrate / 45 h / Heating

With sulfuric acid; toluene-4-sulfonic acid; acetic acid;

DOI:10.1021/jm00111a043

Reference yield:

4-(3,4-dimethoxyphenyl)-4-cyanocyclohexanone (51533-65-4) + 2-(3,4-dimethoxyphenyl)-ethylamine (120-20-7) → 1-(3,4-dimethoxyphenyl)-4-imino>cyclohexanecarbonitrile (133648-61-0)

Guidance literature:

With toluene-4-sulfonic acid; for 45h; Heating;

DOI:10.1021/jm00111a043

Reference yield:

1-(3,4-dimethoxyphenyl)-4-imino>cyclohexanecarbonitrile (133648-61-0) → 1-(3,4-dimethoxyphenyl)-c-4--N-methylamino>-r-cyclohexanecarbonitrile (133648-48-3)

Guidance literature:

Multi-step reaction with 2 steps

1: NaBH₄ / methanol / 2 h / Heating

2: 1.) 85percent HCOOH / 1.) ethanol, reflux, 1 h, 2.) ethanol, reflux, 5 h

With sodium tetrahydroborate; formic acid; In methanol;

DOI:10.1021/jm00111a043

upstream raw materials:

4-(3,4-dimethoxyphenyl)-4-cyanocyclohexanone

2-(3,4-dimethoxyphenyl)-ethylamine

methyl 5-cyano-5-(3,4-dimethoxyphenyl)-2-oxocyclohexanecarboxylate

Downstream raw materials:

1-(3,4-dimethoxyphenyl)-c-4-<<2-(3,4-dimethoxyphenyl)ethyl>amino>-r-1-cyclohexanecarbonitrile

1-(3,4-dimethoxyphenyl)-t-4-<<2-(3,4-dimethoxyphenyl)ethyl>amino>-r-1-cyclohexanecarbonitrile

1-(3,4-dimethoxyphenyl)-c-4--N-methylamino>-r-cyclohexanecarbonitrile

1-(3,4-dimethoxyphenyl)-t-4--N-methylamino>-r-1-cyclohexanecarbonitrile