tert-butyl ((2R,3S)-2-((tert-butyldimethylsilyl)oxy)-4-(N-isopropyl-5-nitro-2-((2S)-pent-4-en-2-yloxy)benzamido)-3-methylbutyl)(methyl)carbamate

Base Information

Chemical Name:tert-butyl ((2R,3S)-2-((tert-butyldimethylsilyl)oxy)-4-(N-isopropyl-5-nitro-2-((2S)-pent-4-en-2-yloxy)benzamido)-3-methylbutyl)(methyl)carbamate
CAS No.:1403480-21-6
Molecular Formula:C₃₂H₅₅N₃O₇Si
Molecular Weight:621.89
Hs Code.:

tert-butyl ((2R,3S)-2-((tert-butyldimethylsilyl)oxy)-4-(N-isopropyl-5-nitro-2-((2S)-pent-4-en-2-yloxy)benzamido)-3-methylbutyl)(methyl)carbamate

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Chemical Property of tert-butyl ((2R,3S)-2-((tert-butyldimethylsilyl)oxy)-4-(N-isopropyl-5-nitro-2-((2S)-pent-4-en-2-yloxy)benzamido)-3-methylbutyl)(methyl)carbamate

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Safty Information:

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Technology Process of tert-butyl ((2R,3S)-2-((tert-butyldimethylsilyl)oxy)-4-(N-isopropyl-5-nitro-2-((2S)-pent-4-en-2-yloxy)benzamido)-3-methylbutyl)(methyl)carbamate

There total 4 articles about tert-butyl ((2R,3S)-2-((tert-butyldimethylsilyl)oxy)-4-(N-isopropyl-5-nitro-2-((2S)-pent-4-en-2-yloxy)benzamido)-3-methylbutyl)(methyl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1255212-71-5
(2S,3R)-4-(tert-butoxycarbonyl(methyl)amino)-3-(tert-butyldimethylsilyloxy)-2-methylbutanoic acid

: 1403480-21-6
tert-butyl ((2R,3S)-2-((tert-butyldimethylsilyl)oxy)-4-(N-isopropyl-5-nitro-2-((2S)-pent-4-en-2-yloxy)benzamido)-3-methylbutyl)(methyl)carbamate

Guidance literature:: Multi-step reaction with 3 steps

1: N-ethyl-N,N-diisopropylamine; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate / dichloromethane / 72 h / Inert atmosphere

2: dimethylsulfide borane complex / tetrahydrofuran / 4 h / 0 - 70 °C / Inert atmosphere

3: N-ethyl-N,N-diisopropylamine; bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride / dichloromethane / 18 h / Inert atmosphere

With dimethylsulfide borane complex; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; dichloromethane;
DOI:10.1021/jm500994n

Reference yield:

: 1403479-92-4
tert-butyl ((2R,3S)-2-((tert-butyldimethylsilyl)oxy)-4-(isopropylamino)-3-methyl-4-oxobutyl)(methyl)carbamate

: 1403480-21-6
tert-butyl ((2R,3S)-2-((tert-butyldimethylsilyl)oxy)-4-(N-isopropyl-5-nitro-2-((2S)-pent-4-en-2-yloxy)benzamido)-3-methylbutyl)(methyl)carbamate

Guidance literature:: Multi-step reaction with 2 steps

1: dimethylsulfide borane complex / tetrahydrofuran / 4 h / 0 - 70 °C / Inert atmosphere

2: N-ethyl-N,N-diisopropylamine; bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride / dichloromethane / 18 h / Inert atmosphere

With dimethylsulfide borane complex; bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; dichloromethane;
DOI:10.1021/jm500994n

Reference yield:

: 1255213-22-9
C₁₂H₁₃NO₅

: 1393801-86-9
tert-butyl ((2R,3R)-2-((tert-butyldimethylsilyl)oxy)-4-(isopropylamino)-3-methylbutyl)(methyl)carbamate

: 1403480-21-6
tert-butyl ((2R,3S)-2-((tert-butyldimethylsilyl)oxy)-4-(N-isopropyl-5-nitro-2-((2S)-pent-4-en-2-yloxy)benzamido)-3-methylbutyl)(methyl)carbamate

Guidance literature:: With bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; N-ethyl-N,N-diisopropylamine; In dichloromethane; for 18h; Inert atmosphere;
DOI:10.1021/jm500994n