N-[4-[2-propynyl-[(6S)-4,6,7,8-tetrahydro-2-(hydroxymethyl)-4-oxo-1H cyclopenta[g]quinazolin-6-yl]amino]benzoyl]-L-γ-glutamyl-D-glutamic acid tris(1,1-dimethylethyl) ester

Base Information

Chemical Name:N-[4-[2-propynyl-[(6S)-4,6,7,8-tetrahydro-2-(hydroxymethyl)-4-oxo-1H cyclopenta[g]quinazolin-6-yl]amino]benzoyl]-L-γ-glutamyl-D-glutamic acid tris(1,1-dimethylethyl) ester
CAS No.:1445098-41-8
Molecular Formula:C₄₄H₅₇N₅O₁₀
Molecular Weight:815.964
Hs Code.:

N-[4-[2-propynyl-[(6S)-4,6,7,8-tetrahydro-2-(hydroxymethyl)-4-oxo-1H cyclopenta[g]quinazolin-6-yl]amino]benzoyl]-L-γ-glutamyl-D-glutamic acid tris(1,1-dimethylethyl) ester

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Chemical Property of N-[4-[2-propynyl-[(6S)-4,6,7,8-tetrahydro-2-(hydroxymethyl)-4-oxo-1H cyclopenta[g]quinazolin-6-yl]amino]benzoyl]-L-γ-glutamyl-D-glutamic acid tris(1,1-dimethylethyl) ester

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Technology Process of N-[4-[2-propynyl-[(6S)-4,6,7,8-tetrahydro-2-(hydroxymethyl)-4-oxo-1H cyclopenta[g]quinazolin-6-yl]amino]benzoyl]-L-γ-glutamyl-D-glutamic acid tris(1,1-dimethylethyl) ester

There total 2 articles about N-[4-[2-propynyl-[(6S)-4,6,7,8-tetrahydro-2-(hydroxymethyl)-4-oxo-1H cyclopenta[g]quinazolin-6-yl]amino]benzoyl]-L-γ-glutamyl-D-glutamic acid tris(1,1-dimethylethyl) ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 38.0%

: 1356166-26-1
(6S)-4,N-((2-(hydroxymethyl)-4-oxo-3,4,7,8-tetrahydro-3H-cyclopenta[g]quinazolin-6-yl)-N-(prop-2-ynyl)amino)benzoic acid

: 145817-20-5
L-γ-glutamyl-D-glutamic acid tris(1,1-dimethylethyl)ester

: 1445098-41-8
N-[4-[2-propynyl-[(6S)-4,6,7,8-tetrahydro-2-(hydroxymethyl)-4-oxo-1H cyclopenta[g]quinazolin-6-yl]amino]benzoyl]-L-γ-glutamyl-D-glutamic acid tris(1,1-dimethylethyl) ester

Guidance literature:: With 4-methyl-morpholine; 1-hydroxybenzotriazol-hydrate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide; Large scale;
DOI:10.1021/jm400490e

Reference yield:

: 1445098-26-9
N-[N-[(phenylmethoxy)carbonyl]-L-γ-glutamyl]-D-glutamic acid tris(1,1-dimethylethyl) ester

: 1445098-41-8
N-[4-[2-propynyl-[(6S)-4,6,7,8-tetrahydro-2-(hydroxymethyl)-4-oxo-1H cyclopenta[g]quinazolin-6-yl]amino]benzoyl]-L-γ-glutamyl-D-glutamic acid tris(1,1-dimethylethyl) ester

Guidance literature:: Multi-step reaction with 2 steps

1: 5%-palladium/activated carbon; hydrogen / ethanol

2: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; 1-hydroxybenzotriazol-hydrate; 4-methyl-morpholine / N,N-dimethyl-formamide / Large scale

With 4-methyl-morpholine; 5%-palladium/activated carbon; hydrogen; 1-hydroxybenzotriazol-hydrate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In ethanol; N,N-dimethyl-formamide;
DOI:10.1021/jm400490e