((6R,7R)-8-oxo-3-(((2-oxo-2H-chromen-7-yl)oxy)methyl)-7-(2-phenylacetamido)-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid 5,5-dioxide)

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Chemical Name:((6R,7R)-8-oxo-3-(((2-oxo-2H-chromen-7-yl)oxy)methyl)-7-(2-phenylacetamido)-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid 5,5-dioxide)
CAS No.:1450821-58-5
Molecular Formula:C₂₅H₂₀N₂O₉S
Molecular Weight:524.508
Hs Code.:

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Chemical Property of ((6R,7R)-8-oxo-3-(((2-oxo-2H-chromen-7-yl)oxy)methyl)-7-(2-phenylacetamido)-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid 5,5-dioxide)

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Technology Process of ((6R,7R)-8-oxo-3-(((2-oxo-2H-chromen-7-yl)oxy)methyl)-7-(2-phenylacetamido)-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid 5,5-dioxide)

There total 4 articles about ((6R,7R)-8-oxo-3-(((2-oxo-2H-chromen-7-yl)oxy)methyl)-7-(2-phenylacetamido)-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid 5,5-dioxide) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

: 1450821-68-7
(6R,7R)-4-methoxybenzyl 8-oxo-3-(((2-oxo-2H-chromen-7-yl)oxy)methyl)-7-(2-phenylacetamido)-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate 5,5-dioxide

: 1450821-58-5
((6R,7R)-8-oxo-3-(((2-oxo-2H-chromen-7-yl)oxy)methyl)-7-(2-phenylacetamido)-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid 5,5-dioxide)

Guidance literature:: With methoxybenzene; trifluoroacetic acid; at 0 - 20 ℃; for 1h;
DOI:10.1021/jm400769b

Reference yield:

: 1450821-66-5
(6R,7R)-4-methoxybenzyl 8-oxo-3-(((2-oxo-2H-chromen-7-yl)oxy)methyl)-7-(2-phenylacetamido)-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate

: 1450821-58-5
((6R,7R)-8-oxo-3-(((2-oxo-2H-chromen-7-yl)oxy)methyl)-7-(2-phenylacetamido)-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid 5,5-dioxide)

Guidance literature:: Multi-step reaction with 3 steps

1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 0 - 20 °C

2: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 0 - 20 °C

3: trifluoroacetic acid; methoxybenzene / 1 h / 0 - 20 °C

With methoxybenzene; 3-chloro-benzenecarboperoxoic acid; trifluoroacetic acid; In dichloromethane;
DOI:10.1021/jm400769b

Reference yield:

: 104146-10-3
(6R,7R)-3-Chloromethyl-8-oxo-7-phenylacetylamino-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid 4-methoxy-benzyl ester

: 1450821-58-5
((6R,7R)-8-oxo-3-(((2-oxo-2H-chromen-7-yl)oxy)methyl)-7-(2-phenylacetamido)-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid 5,5-dioxide)

Guidance literature:: Multi-step reaction with 5 steps

1: sodium iodide / acetone / 2 h / 20 °C

2: potassium carbonate / acetonitrile / 4 h

3: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 0 - 20 °C

4: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 0 - 20 °C

5: trifluoroacetic acid; methoxybenzene / 1 h / 0 - 20 °C

With potassium carbonate; methoxybenzene; 3-chloro-benzenecarboperoxoic acid; trifluoroacetic acid; sodium iodide; In dichloromethane; acetone; acetonitrile;
DOI:10.1021/jm400769b