Technology Process of (+)-C20-desethylbenzylcamptothecin
There total 7 articles about (+)-C20-desethylbenzylcamptothecin which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 3 steps
1: sodium hexamethyldisilazane; 2-[(4-methylphenyl)sulfonyl]-3-phenyl-oxaziridine
2: trifluoroacetic acid / water / 1 h / 20 °C
3: toluene-4-sulfonic acid / toluene / 18 h / Dean-Stark; Reflux; Inert atmosphere
With
sodium hexamethyldisilazane; toluene-4-sulfonic acid; 2-[(4-methylphenyl)sulfonyl]-3-phenyl-oxaziridine; trifluoroacetic acid;
In
water; toluene;
3: |Friedlaender Quinoline Synthesis;
DOI:10.1002/chem.201303633
- Guidance literature:
-
Multi-step reaction with 4 steps
1: acetic acid
2: sodium hexamethyldisilazane; 2-[(4-methylphenyl)sulfonyl]-3-phenyl-oxaziridine
3: trifluoroacetic acid / water / 1 h / 20 °C
4: toluene-4-sulfonic acid / toluene / 18 h / Dean-Stark; Reflux; Inert atmosphere
With
sodium hexamethyldisilazane; toluene-4-sulfonic acid; acetic acid; 2-[(4-methylphenyl)sulfonyl]-3-phenyl-oxaziridine; trifluoroacetic acid;
In
water; toluene;
4: |Friedlaender Quinoline Synthesis;
DOI:10.1002/chem.201303633
- Guidance literature:
-
Multi-step reaction with 2 steps
1: trifluoroacetic acid / water / 1 h / 20 °C
2: toluene-4-sulfonic acid / toluene / 18 h / Dean-Stark; Reflux; Inert atmosphere
With
toluene-4-sulfonic acid; trifluoroacetic acid;
In
water; toluene;
2: |Friedlaender Quinoline Synthesis;
DOI:10.1002/chem.201303633
