Technology Process of (3R,3aR,6R,6aS)-3-hydroxyhexahydro-2H-furo[3.2-b]pyrrol-6-yl 4-methylbenzenesulfonate hydrochloride
There total 9 articles about (3R,3aR,6R,6aS)-3-hydroxyhexahydro-2H-furo[3.2-b]pyrrol-6-yl 4-methylbenzenesulfonate hydrochloride which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 8 steps
1: ethanol; ammonium chloride; zinc / 16 h / Inert atmosphere
2: ammonium hydroxide; ammonia; water / isopropyl alcohol / 16 h / 75 °C
3: sodium carbonate / 1,4-dioxane; water / 1 h / 0 °C
4: pyridine / 19.5 h / 14 - 24 °C
5: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 44 h / 20 - 24 °C
6: hydrogen / palladium 10% on activated carbon / ethanol / 4.5 h
7: sodium carbonate / 1,4-dioxane; water / 2.27 h
8: hydrogenchloride / 1,4-dioxane / 1 h / 20 °C
With
pyridine; hydrogenchloride; ammonium hydroxide; ethanol; ammonia; water; hydrogen; sodium carbonate; ammonium chloride; 3-chloro-benzenecarboperoxoic acid; zinc;
palladium 10% on activated carbon;
In
1,4-dioxane; ethanol; dichloromethane; water; isopropyl alcohol;
- Guidance literature:
-
Multi-step reaction with 4 steps
1: Oxone; 1,1,1-trifluoro-2-propanone; sodium hydrogencarbonate / water; acetonitrile / 0 °C
2: hydrogen / palladium 10% on activated carbon / ethanol / 4.5 h
3: sodium carbonate / 1,4-dioxane; water / 2.27 h
4: hydrogenchloride / 1,4-dioxane / 1 h / 20 °C
With
hydrogenchloride; Oxone; 1,1,1-trifluoro-2-propanone; hydrogen; sodium hydrogencarbonate; sodium carbonate;
palladium 10% on activated carbon;
In
1,4-dioxane; ethanol; water; acetonitrile;
- Guidance literature:
-
Multi-step reaction with 5 steps
1: pyridine / 19.5 h / 14 - 24 °C
2: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 44 h / 20 - 24 °C
3: hydrogen / palladium 10% on activated carbon / ethanol / 4.5 h
4: sodium carbonate / 1,4-dioxane; water / 2.27 h
5: hydrogenchloride / 1,4-dioxane / 1 h / 20 °C
With
pyridine; hydrogenchloride; hydrogen; sodium carbonate; 3-chloro-benzenecarboperoxoic acid;
palladium 10% on activated carbon;
In
1,4-dioxane; ethanol; dichloromethane; water;
![(3S,3aS,6S,6aS)-6-bromohexahydrofuro[3,2-b]furan-3-yI 4-methylbenzenesulfonate](/Databaselist/images/loading.webp)
