CHEMPACIFIC 38137

Base Information

• Chemical Name: CHEMPACIFIC 38137
• CAS No.: 10177-21-6
• Molecular Formula: C6H5Cl2N
• Molecular Weight: 162.018
• Hs Code.: 2933399090
• Mol file: 10177-21-6.mol

Synonyms:4-chloro-2-(chloromethyl)pyridine;

Chemical Property of CHEMPACIFIC 38137

Chemical Property:

• Vapor Pressure: 0.207mmHg at 25°C
• Boiling Point: 216.3oC at 760 mmHg
• PKA: 2.01±0.10(Predicted)
• Flash Point: 105.1oC
• PSA: 12.89000
• Density: 1.324g/cm3
• LogP: 2.47380

Purity/Quality:

98%,99%, ^*data from raw suppliers

4-Chloro-2-(chloromethyl)pyridine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 4-Chloro-2-(chloromethyl)pyridine is an intermediate in the synthesis of 1-(4-Chloropyridin-2-yl)-N-methylmethanamine (C380680), which is used in the preparation of indole derivatives as inhibitors between MDM2 and p53 interactions.

Technology Process of CHEMPACIFIC 38137

There total 10 articles about CHEMPACIFIC 38137 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.2%

(4-chloropyridin-2-yl)methanol (63071-10-3) → 4-chloro-2-chloromethyl pyridine (10177-21-6)

Guidance literature:

With thionyl chloride; In dichloromethane; at 20 ℃; for 5.5h; Cooling with ice;

Reference yield: 35.0%

4-chloro-2-picoline-N-oxide (696-08-2) → 4-chloro-2-chloromethyl pyridine (10177-21-6)

Guidance literature:

With p-toluenesulfonyl chloride; In 1,4-dioxane; for 16h; Heating;

DOI:10.1016/0040-4020(82)80106-3

Reference yield:

2-(chloromethyl)pyridine N-oxide hydrochloride (20979-34-4) → 2-chloromethylpyridine (4377-33-7) + α,α-dichloropicoline (4377-35-9) + 4-chloro-2-chloromethyl pyridine (10177-21-6) + 6-chloro-2-chloromethylpyridine (78846-88-5)

Guidance literature:

With trichlorophosphate; In toluene; for 4h; Heating;

DOI:10.1016/0040-4020(82)80106-3

upstream raw materials:

4-chloro-2-picoline-N-oxide

2-(chloromethyl)pyridine N-oxide hydrochloride

(4-chloropyridin-2-yl)methanol

(4-chloropyridin-2-yl)methyl acetate

Downstream raw materials:

(4-chloropyridin-2-yl)methanamine

N-phenyl-4-chloro-2-pyridinecarboxamide

4-chloro-2-methylaminomethylpyridine

2-(aminomethyl)-4-(dimethylamino)pyridine

Refernces

• 1、 Ribelli, Thomas G.,Fantin, Marco,Daran, Jean-Claude,Augustine, Kyle F.,Poli, Rinaldo,Matyjaszewski, Krzysztof. "Synthesis and Characterization of the Most Active Copper ATRP Catalyst Based on Tris[(4-dimethylaminopyridyl)methyl]amine". . p. 1525 - 1534. Retrieved 2018.
• 2、 Salaam, Jeremy,Pilet, Guillaume,Hasserodt, Jens. "Multiple Sulfonation of Picolyl-Based Complexes Rendering Them Highly Water-Compatible". . p. 13812 - 13816. Retrieved 2020.
• 3、 -. "NITROGENOUS HETEROCYCLIC DERIVATIVES AND THEIR APPLICATION IN DRUGS". Paragraph 00416. . Retrieved 2015/07/07.