trans-(+/-)-β-Benzyl-δ-methylvalerolactone

Base Information

• Chemical Name: trans-(+/-)-β-Benzyl-δ-methylvalerolactone
• CAS No.: 74591-87-0
• Molecular Formula: C₁₃H₁₆O₂
• Molecular Weight: 204.269
• Mol file: 74591-87-0.mol

Synonyms:

Chemical Property of trans-(+/-)-β-Benzyl-δ-methylvalerolactone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of trans-(+/-)-β-Benzyl-δ-methylvalerolactone

There total 5 articles about trans-(+/-)-β-Benzyl-δ-methylvalerolactone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.5%

parasorbic acid (10385-75-8) + benzylmagnesium chloride (6921-34-2) → trans-(+/-)-β-Benzyl-δ-methylvalerolactone (74591-87-0)

Guidance literature:

In diethyl ether; 1.) -78 deg C; 2.) 25 deg C;

DOI:10.1021/jo01309a009

Reference yield:

4-pentyn-2-ol (2117-11-5) → trans-(+/-)-β-Benzyl-δ-methylvalerolactone (74591-87-0)

Guidance literature:

Multi-step reaction with 5 steps

2: quinoline / Pd/BaSO₄ / ethyl acetate

3: NaOH / ethanol; H₂O / 1 h / Heating

4: benzene / 1.5 h / Heating

5: 68.5 percent / diethyl ether / 1.) -78 deg C; 2.) 25 deg C

With quinoline; sodium hydroxide; Pd-BaSO₄; In diethyl ether; ethanol; water; ethyl acetate; benzene;

DOI:10.1021/jo01309a009

Reference yield:

Methyl 5-Hydroxy-2-hexynoate (166389-90-8) → trans-(+/-)-β-Benzyl-δ-methylvalerolactone (74591-87-0)

Guidance literature:

Multi-step reaction with 4 steps

1: quinoline / Pd/BaSO₄ / ethyl acetate

2: NaOH / ethanol; H₂O / 1 h / Heating

3: benzene / 1.5 h / Heating

4: 68.5 percent / diethyl ether / 1.) -78 deg C; 2.) 25 deg C

With quinoline; sodium hydroxide; Pd-BaSO₄; In diethyl ether; ethanol; water; ethyl acetate; benzene;

DOI:10.1021/jo01309a009

upstream raw materials:

parasorbic acid

benzylmagnesium chloride

4-pentyn-2-ol

5-Hydroxy-2-hexenoic Acid