1-<2'-deoxy-5'-O-(4,4'-dimethoxytrityl)-β-D-ribofuranosyl>-5-<<2,2,6,6-tetramethyl-1-(oxyl)piperidin-4-yl>amino>pyrimidine-2,4(1H,3H)-dione

Base Information

• Chemical Name: 1-<2'-deoxy-5'-O-(4,4'-dimethoxytrityl)-β-D-ribofuranosyl>-5-<<2,2,6,6-tetramethyl-1-(oxyl)piperidin-4-yl>amino>pyrimidine-2,4(1H,3H)-dione
• CAS No.: 136136-27-1
• Molecular Formula: C₃₉H₄₇N₄O₈
• Molecular Weight: 699.824
• Mol file: 136136-27-1.mol

Synonyms:

Chemical Property of 1-<2'-deoxy-5'-O-(4,4'-dimethoxytrityl)-β-D-ribofuranosyl>-5-<<2,2,6,6-tetramethyl-1-(oxyl)piperidin-4-yl>amino>pyrimidine-2,4(1H,3H)-dione

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-<2'-deoxy-5'-O-(4,4'-dimethoxytrityl)-β-D-ribofuranosyl>-5-<<2,2,6,6-tetramethyl-1-(oxyl)piperidin-4-yl>amino>pyrimidine-2,4(1H,3H)-dione

There total 3 articles about 1-<2'-deoxy-5'-O-(4,4'-dimethoxytrityl)-β-D-ribofuranosyl>-5-<<2,2,6,6-tetramethyl-1-(oxyl)piperidin-4-yl>amino>pyrimidine-2,4(1H,3H)-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

4,4'-dimethoxytrityl chloride (40615-36-9) + 1-(2'-deoxy-β-D-ribofuranosyl)-5-<<2,2,6,6-tetramethyl-1-(oxyl)piperidin-4-yl>amino>pyrimidine-2,4(1H,3H)-dione (76462-96-9) → 1-<2'-deoxy-5'-O-(4,4'-dimethoxytrityl)-β-D-ribofuranosyl>-5-<<2,2,6,6-tetramethyl-1-(oxyl)piperidin-4-yl>amino>pyrimidine-2,4(1H,3H)-dione (136136-27-1)

Guidance literature:

With pyridine; for 6h; Ambient temperature;

DOI:10.1002/hlca.19910740407

Reference yield:

2'-deoxyuridine (951-78-0,63844-76-8) → 1-<2'-deoxy-5'-O-(4,4'-dimethoxytrityl)-β-D-ribofuranosyl>-5-<<2,2,6,6-tetramethyl-1-(oxyl)piperidin-4-yl>amino>pyrimidine-2,4(1H,3H)-dione (136136-27-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 26 percent / 1 N H₂SO₄ (pH 5) / H₂O / 10 h / 100 °C

2: 71 percent / pyridine / 6 h / Ambient temperature

With pyridine; sulfuric acid; In water;

DOI:10.1002/hlca.19910740407

Reference yield:

4-amino-2,2,6,6-tetramethyl-1-piperidine-1-oxyl (14691-88-4,78774-22-8) → 1-<2'-deoxy-5'-O-(4,4'-dimethoxytrityl)-β-D-ribofuranosyl>-5-<<2,2,6,6-tetramethyl-1-(oxyl)piperidin-4-yl>amino>pyrimidine-2,4(1H,3H)-dione (136136-27-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 26 percent / 1 N H₂SO₄ (pH 5) / H₂O / 10 h / 100 °C

2: 71 percent / pyridine / 6 h / Ambient temperature

With pyridine; sulfuric acid; In water;

DOI:10.1002/hlca.19910740407

upstream raw materials:

4,4'-dimethoxytrityl chloride

1-(2'-deoxy-β-D-ribofuranosyl)-5-<<2,2,6,6-tetramethyl-1-(oxyl)piperidin-4-yl>amino>pyrimidine-2,4(1H,3H)-dione

2'-deoxyuridine

4-amino-2,2,6,6-tetramethyl-1-piperidine-1-oxyl

Downstream raw materials:

C₄₈H₆₄N₆O₉P

1-<2'-deoxy-5'-O-(4,4'-dimethoxytrityl)-β-D-ribofuranosyl>-5-<<2,2,6,6-tetramethyl-1-(oxyl)piperidin-4-yl>amino>pyrimidine-2,4(1H,3H)-dione 3'<(2-chlorophenyl) triethylammonium phosphate>