4-(4-Chloro-benzenesulfonylaminocarbonyl)-N-((S)-2-methyl-1-{methyl-[(3,3,3-trifluoro-1-isopropyl-2-oxo-propylcarbamoyl)-methyl]-carbamoyl}-propyl)-benzamide

Base Information

Chemical Name:4-(4-Chloro-benzenesulfonylaminocarbonyl)-N-((S)-2-methyl-1-{methyl-[(3,3,3-trifluoro-1-isopropyl-2-oxo-propylcarbamoyl)-methyl]-carbamoyl}-propyl)-benzamide
CAS No.:129601-47-4
Molecular Formula:C₂₈H₃₂ClF₃N₄O₇S
Molecular Weight:661.099
Hs Code.:

4-(4-Chloro-benzenesulfonylaminocarbonyl)-N-((S)-2-methyl-1-{methyl-[(3,3,3-trifluoro-1-isopropyl-2-oxo-propylcarbamoyl)-methyl]-carbamoyl}-propyl)-benzamide

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Chemical Property of 4-(4-Chloro-benzenesulfonylaminocarbonyl)-N-((S)-2-methyl-1-{methyl-[(3,3,3-trifluoro-1-isopropyl-2-oxo-propylcarbamoyl)-methyl]-carbamoyl}-propyl)-benzamide

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Technology Process of 4-(4-Chloro-benzenesulfonylaminocarbonyl)-N-((S)-2-methyl-1-{methyl-[(3,3,3-trifluoro-1-isopropyl-2-oxo-propylcarbamoyl)-methyl]-carbamoyl}-propyl)-benzamide

There total 12 articles about 4-(4-Chloro-benzenesulfonylaminocarbonyl)-N-((S)-2-methyl-1-{methyl-[(3,3,3-trifluoro-1-isopropyl-2-oxo-propylcarbamoyl)-methyl]-carbamoyl}-propyl)-benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1149-26-4
(S)-N-(benzyloxycarbonyl)valine

: 129601-47-4,137302-09-1
4-(4-Chloro-benzenesulfonylaminocarbonyl)-N-((S)-2-methyl-1-{methyl-[(3,3,3-trifluoro-1-isopropyl-2-oxo-propylcarbamoyl)-methyl]-carbamoyl}-propyl)-benzamide

Guidance literature:: Multi-step reaction with 6 steps

1: CDI / CH₂Cl₂ / 16 h / Ambient temperature

2: 1 N aq. KOH / ethanol / 16 h / Ambient temperature

3: 1.) CDI, 2.) Et₃N / 1.) CH₂Cl₂, RT, 2 h, 2.) CH₂Cl₂, 16 h

4: H₂ / 10percent Pd/C / ethanol / 3 h / 2327.2 Torr

5: HOBT, 1-<3-(dimethylamino)propyl>-3-ethylcarbodiimide hydrochloride (WSCDI) / tetrahydrofuran / 4.5 h / 0 - 20 °C

6: Dess-Martin periodinane reagent, CF₃COOH / tetrahydrofuran; CH₂Cl₂ / 16 h / Ambient temperature

With potassium hydroxide; hydrogen; benzotriazol-1-ol; Dess-Martin periodane; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; 1,1'-carbonyldiimidazole; trifluoroacetic acid; palladium on activated charcoal; In tetrahydrofuran; ethanol; dichloromethane;
DOI:10.1021/jm00082a005

Reference yield:

: [((S)-2-Benzyloxycarbonylamino-3-methyl-butyryl)-methyl-amino]-acetic acid ethyl ester

: 129601-47-4,137302-09-1
4-(4-Chloro-benzenesulfonylaminocarbonyl)-N-((S)-2-methyl-1-{methyl-[(3,3,3-trifluoro-1-isopropyl-2-oxo-propylcarbamoyl)-methyl]-carbamoyl}-propyl)-benzamide

Guidance literature:: Multi-step reaction with 5 steps

1: 1 N aq. KOH / ethanol / 16 h / Ambient temperature

2: 1.) CDI, 2.) Et₃N / 1.) CH₂Cl₂, RT, 2 h, 2.) CH₂Cl₂, 16 h

3: H₂ / 10percent Pd/C / ethanol / 3 h / 2327.2 Torr

4: HOBT, 1-<3-(dimethylamino)propyl>-3-ethylcarbodiimide hydrochloride (WSCDI) / tetrahydrofuran / 4.5 h / 0 - 20 °C

5: Dess-Martin periodinane reagent, CF₃COOH / tetrahydrofuran; CH₂Cl₂ / 16 h / Ambient temperature

With potassium hydroxide; hydrogen; benzotriazol-1-ol; Dess-Martin periodane; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; 1,1'-carbonyldiimidazole; trifluoroacetic acid; palladium on activated charcoal; In tetrahydrofuran; ethanol; dichloromethane;
DOI:10.1021/jm00082a005

Reference yield:

: ((S)-2-Methyl-1-{methyl-[(3,3,3-trifluoro-2-hydroxy-1-isopropyl-propylcarbamoyl)-methyl]-carbamoyl}-propyl)-carbamic acid benzyl ester

: 129601-47-4,137302-09-1
4-(4-Chloro-benzenesulfonylaminocarbonyl)-N-((S)-2-methyl-1-{methyl-[(3,3,3-trifluoro-1-isopropyl-2-oxo-propylcarbamoyl)-methyl]-carbamoyl}-propyl)-benzamide

Guidance literature:: Multi-step reaction with 3 steps

1: H₂ / 10percent Pd/C / ethanol / 3 h / 2327.2 Torr

2: HOBT, 1-<3-(dimethylamino)propyl>-3-ethylcarbodiimide hydrochloride (WSCDI) / tetrahydrofuran / 4.5 h / 0 - 20 °C

3: Dess-Martin periodinane reagent, CF₃COOH / tetrahydrofuran; CH₂Cl₂ / 16 h / Ambient temperature

With hydrogen; benzotriazol-1-ol; Dess-Martin periodane; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; trifluoroacetic acid; palladium on activated charcoal; In tetrahydrofuran; ethanol; dichloromethane;
DOI:10.1021/jm00082a005