Technology Process of 4-Bromo-benzoic acid (3aR,8S,8aR)-8,8a-dimethyl-5-oxo-octahydro-4,8-methano-azulen-3a-ylmethyl ester
There total 5 articles about 4-Bromo-benzoic acid (3aR,8S,8aR)-8,8a-dimethyl-5-oxo-octahydro-4,8-methano-azulen-3a-ylmethyl ester which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 25 mg / LiAlH4 / diethyl ether / 1) 0 deg C, 30 min, 2) r.t., 30 min
2: 1) ozonized O2, 2) H2O, 35percent H2O2 / 1) EtOAc, -70 deg C, 1.5 h, 2) 50-60 deg C, 2 h
3: 32 mg / pyridine / 48 h / Ambient temperature
With
pyridine; ozone-containing oxygen; lithium aluminium tetrahydride; water; dihydrogen peroxide;
In
diethyl ether;
DOI:10.1016/0031-9422(90)85041-D
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 95 mg / diethyl ether / 4 h
2: 81 mg / LiAlH4 / diethyl ether / 1 h / 0 °C
3: 1) ozonized O2, 2) H2O, 35percent H2O2 / 1) EtOAc, -70 deg C, 1.5 h, 2) 50-60 deg C, 2 h
4: 32 mg / pyridine / 48 h / Ambient temperature
With
pyridine; ozone-containing oxygen; lithium aluminium tetrahydride; water; dihydrogen peroxide;
In
diethyl ether;
DOI:10.1016/0031-9422(90)85041-D
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 81 mg / LiAlH4 / diethyl ether / 1 h / 0 °C
2: 1) ozonized O2, 2) H2O, 35percent H2O2 / 1) EtOAc, -70 deg C, 1.5 h, 2) 50-60 deg C, 2 h
3: 32 mg / pyridine / 48 h / Ambient temperature
With
pyridine; ozone-containing oxygen; lithium aluminium tetrahydride; water; dihydrogen peroxide;
In
diethyl ether;
DOI:10.1016/0031-9422(90)85041-D
