5-Ethyl-3-phenyl-1,3-oxazolidin-2-one

Base Information

• Chemical Name: 5-Ethyl-3-phenyl-1,3-oxazolidin-2-one
• CAS No.: 101835-17-0
• Molecular Formula: C11H13NO2
• Molecular Weight: 191.23
• DSSTox Substance ID: DTXSID70542705
• Nikkaji Number: J302.710D
• Mol file: 101835-17-0.mol

Synonyms:101835-17-0;5-ethyl-3-phenyl-1,3-oxazolidin-2-one;5-Ethyl-3-phenyloxazolidin-2-one;SCHEMBL16588413;DTXSID70542705;5-ethyl-3-phenyl-oxazolidin-2-one

Chemical Property of 5-Ethyl-3-phenyl-1,3-oxazolidin-2-one

Chemical Property:

• XLogP3: 2.4
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 2
• Exact Mass: 191.094628657
• Heavy Atom Count: 14
• Complexity: 211

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCC1CN(C(=O)O1)C2=CC=CC=C2

Technology Process of 5-Ethyl-3-phenyl-1,3-oxazolidin-2-one

There total 10 articles about 5-Ethyl-3-phenyl-1,3-oxazolidin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

carbon dioxide (124-38-9,18923-20-1) + 2-Ethyl-1-phenyl-aziridine (123265-53-2) → 5-ethyl-3-phenyl-1,3-oxazolidine-2-one (101835-17-0)

Guidance literature:

With tetraphenylstibonium bromide; In acetonitrile; at 60 ℃; for 24h;

Reference yield: 80.0%

ethyloxirane (106-88-7) + carbon dioxide (124-38-9,18923-20-1) + aniline (62-53-3) → 5-ethyl-3-phenyl-1,3-oxazolidine-2-one (101835-17-0) + 1,2-dihydroxybutane (584-03-2)

Guidance literature:

With C₂₄H₂₅N₄O₃⁽¹⁺⁾*I^(1-); 1,8-diazabicyclo[5.4.0]undec-7-ene; at 110 ℃; for 25h; under 3750.38 Torr; Autoclave;

DOI:10.1039/c9ob00224c

Reference yield: 77.0%

4-ethyl-2-phenylimino-1,3-oxathiolane (137146-10-2) → 5-ethyl-3-phenyl-1,3-oxazolidine-2-one (101835-17-0)

Guidance literature:

With ethyloxirane; aluminium trichloride; at 40 ℃; for 0.3h;

DOI:10.1246/bcsj.64.2661

upstream raw materials:

ethyloxirane

phenyl isocyanate

phenyl isothiocyanate

4-ethyl-2-phenylimino-1,3-oxathiolane