(S)-GLYCIDIC ACID

Base Information

• Chemical Name: (S)-GLYCIDIC ACID
• CAS No.: 114990-90-8
• Molecular Formula: C₃H₄O₃
• Molecular Weight: 88.063
• Mol file: 114990-90-8.mol

Synonyms:

Chemical Property of (S)-GLYCIDIC ACID

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

2-Oxiranecarboxylicacid,(2S)- 96% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (S)-GLYCIDIC ACID

There total 4 articles about (S)-GLYCIDIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

(R)-oxiranemethanol (57044-25-4) → glycidic acid (114990-90-8)

Guidance literature:

With ruthenium trichloride; sodium periodate;

DOI:10.1021/ol000034b

Reference yield: 69.56%

methyl (2S)-glycidate (4538-50-5,85485-00-3,111058-32-3,118712-39-3) → glycidic acid (114990-90-8)

Guidance literature:

With lithium hydroxide monohydrate; water; In tetrahydrofuran; methanol; at 25 ℃;

Reference yield: 24.0%

(R)-serine ethyl ester (145937-64-0) → glycidic acid (114990-90-8)

Guidance literature:

(R)-serine ethyl ester; With hydrogenchloride; sodium nitrite; at 0 ℃; for 6h;

With potassium hydroxide; In ethanol; at 0 - 20 ℃; for 16h;

With hydrogenchloride; In water; at 20 ℃; for 0.5h; Further stages.;

DOI:10.1016/j.bmc.2008.02.024

upstream raw materials:

(R)-oxiranemethanol

(R)-serine ethyl ester

(S)-oxiranemethanol

methyl (2S)-glycidate

Downstream raw materials:

(S)-2-hydroxy-3-(1H-indol-3-yl)-propionic acid

Refernces

• 1、 Groarke, Michelle,McKervey, M. Anthony,Miel, Hugues,Nieuwenhuyzen, Mark. "Nonracemic 2-diazo-1-oxiranyl-ethanone, a versatile chiral epoxide educt in diazocarbonyl reactions". . p. 2393 - 2395. Retrieved 2000.
• 2、 -. "INTERMEDIATES AND METHODS FOR THE PREPARATION OF EPOTHILONES". Page/Page column 15. . Retrieved 2009/06/27.