(R)-3,3,3-Trifluoro-2-methoxy-2-phenyl-propionic acid (R)-22-((S)-2,2-dimethyl-[1,3]dioxan-4-yl)-1-methyl-docosyl ester

Base Information

• Chemical Name: (R)-3,3,3-Trifluoro-2-methoxy-2-phenyl-propionic acid (R)-22-((S)-2,2-dimethyl-[1,3]dioxan-4-yl)-1-methyl-docosyl ester
• CAS No.: 142922-48-3
• Molecular Formula: C₃₉H₆₅F₃O₅
• Molecular Weight: 670.937
• Mol file: 142922-48-3.mol

Synonyms:

Chemical Property of (R)-3,3,3-Trifluoro-2-methoxy-2-phenyl-propionic acid (R)-22-((S)-2,2-dimethyl-[1,3]dioxan-4-yl)-1-methyl-docosyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (R)-3,3,3-Trifluoro-2-methoxy-2-phenyl-propionic acid (R)-22-((S)-2,2-dimethyl-[1,3]dioxan-4-yl)-1-methyl-docosyl ester

There total 4 articles about (R)-3,3,3-Trifluoro-2-methoxy-2-phenyl-propionic acid (R)-22-((S)-2,2-dimethyl-[1,3]dioxan-4-yl)-1-methyl-docosyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-(O-α-D-Glucopyranosyl)-3S,25R-hexacosanediol hexaacetate (142922-38-1,143004-37-9) → (R)-3,3,3-Trifluoro-2-methoxy-2-phenyl-propionic acid (R)-22-((S)-2,2-dimethyl-[1,3]dioxan-4-yl)-1-methyl-docosyl ester (142922-48-3)

Guidance literature:

Multi-step reaction with 4 steps

1: 3 mg / Na₂CO₃ / methanol / 16 h / Ambient temperature

2: 1.0 mg / H₂SO₄, H₂O / methanol / 22 h / Heating

3: p-TsOH / 24 h / Ambient temperature

4: pyridine, 4-dimethylaminopyridine / 24 h / Ambient temperature

With pyridine; dmap; sulfuric acid; water; sodium carbonate; toluene-4-sulfonic acid; In methanol;

DOI:10.1016/S0040-4020(01)89033-5

Reference yield:

1-(O-α-D-Glucopyranosyl)-3S,25R-hexacosanediol (143004-36-8) → (R)-3,3,3-Trifluoro-2-methoxy-2-phenyl-propionic acid (R)-22-((S)-2,2-dimethyl-[1,3]dioxan-4-yl)-1-methyl-docosyl ester (142922-48-3)

Guidance literature:

Multi-step reaction with 3 steps

1: 1.0 mg / H₂SO₄, H₂O / methanol / 22 h / Heating

2: p-TsOH / 24 h / Ambient temperature

3: pyridine, 4-dimethylaminopyridine / 24 h / Ambient temperature

With pyridine; dmap; sulfuric acid; water; toluene-4-sulfonic acid; In methanol;

DOI:10.1016/S0040-4020(01)89033-5

Reference yield:

1,3S,25R-Hexacosanetriol (142922-40-5) → (R)-3,3,3-Trifluoro-2-methoxy-2-phenyl-propionic acid (R)-22-((S)-2,2-dimethyl-[1,3]dioxan-4-yl)-1-methyl-docosyl ester (142922-48-3)

Guidance literature:

Multi-step reaction with 2 steps

1: p-TsOH / 24 h / Ambient temperature

2: pyridine, 4-dimethylaminopyridine / 24 h / Ambient temperature

With pyridine; dmap; toluene-4-sulfonic acid;

DOI:10.1016/S0040-4020(01)89033-5

upstream raw materials:

(S)-(+)-2-methoxy-2-trifluoromethyl-2-phenylacetyl chloride

(R)-23-((S)-2,2-Dimethyl-[1,3]dioxan-4-yl)-tricosan-2-ol

1-(O-α-D-Glucopyranosyl)-3S,25R-hexacosanediol hexaacetate

1,3S,25R-Hexacosanetriol