(6S,7S)-7-{2-[(Z)-Methoxyimino]-2-[2-(trityl-amino)-thiazol-4-yl]-acetylamino}-8-oxo-4-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid tert-butyl ester

Base Information

• Chemical Name: (6S,7S)-7-{2-[(Z)-Methoxyimino]-2-[2-(trityl-amino)-thiazol-4-yl]-acetylamino}-8-oxo-4-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid tert-butyl ester
• CAS No.: 102062-23-7
• Molecular Formula: C₃₆H₃₅N₅O₅S₂
• Molecular Weight: 681.836
• Mol file: 102062-23-7.mol

Synonyms:

Chemical Property of (6S,7S)-7-{2-[(Z)-Methoxyimino]-2-[2-(trityl-amino)-thiazol-4-yl]-acetylamino}-8-oxo-4-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid tert-butyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (6S,7S)-7-{2-[(Z)-Methoxyimino]-2-[2-(trityl-amino)-thiazol-4-yl]-acetylamino}-8-oxo-4-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid tert-butyl ester

There total 7 articles about (6S,7S)-7-{2-[(Z)-Methoxyimino]-2-[2-(trityl-amino)-thiazol-4-yl]-acetylamino}-8-oxo-4-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 37.5%

tert-butyl 7β-<2-(2-tritylaminothiazol-4-yl)-(Z)-2-methoxyiminoacetamido>-3-(4-nitrobenzylthio)-4-hydroxy-1-dethia-2-thiacepham-4-carboxylate (102192-28-9,124918-19-0,124986-34-1) → (6S,7S)-7-{2-[(Z)-Methoxyimino]-2-[2-(trityl-amino)-thiazol-4-yl]-acetylamino}-8-oxo-4-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid tert-butyl ester (102062-23-7) + tert-butyl 7β-<2-(2-tritylaminothiazol-4-yl)-(Z)-2-methoxyiminoacetamido>-3-(4-nitrobenzylthio)-1-dethia-2-thia-3-cephem-4-carboxylate (102142-87-0,124918-26-9)

Guidance literature:

With diphosphorus tetraiodide; In pyridine;

DOI:10.3987/COM-88-S127

Reference yield: 26.7%

tert-butyl 7β-<2-(2-tritylaminothiazol-4-yl)-(Z)-2-methoxyiminoacetamido>-3-<(5-methyl-1,3,4-thiadiazol-2-yl)thio>-4-hydroxy-1-dethia-2-thiacepham-4-carboxylate (102142-89-2,124918-17-8,124918-18-9) → (6S,7S)-7-{2-[(Z)-Methoxyimino]-2-[2-(trityl-amino)-thiazol-4-yl]-acetylamino}-8-oxo-4-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid tert-butyl ester (102062-23-7) + tert-butyl 7β-<2-(2-tritylaminothiazol-4-yl)-(Z)-2-methoxyiminoacetamido>-3-<(5-methyl-1,3,4-thiadiazol-2-yl)thio>-1-dethia-2-thia-3-cephem-4-carboxylate (102142-90-5,124918-25-8)

Guidance literature:

With diphosphorus tetraiodide; In pyridine;

DOI:10.3987/COM-88-S127

Reference yield: 20.6%

tert-butyl 7β-<2-(2-tritylaminothiazol-4-yl)-(Z)-2-methoxyiminoacetamido>-3-(4-nitrophenylthio)-4-hydroxy-1-dethia-2-thiacepham-4-carboxylate (102191-76-4,124986-33-0) → (6S,7S)-7-{2-[(Z)-Methoxyimino]-2-[2-(trityl-amino)-thiazol-4-yl]-acetylamino}-8-oxo-4-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid tert-butyl ester (102062-23-7) + tert-butyl 7β-<2-(2-tritylaminothiazol-4-yl)-(Z)-2-methoxyiminoacetamido>-3-(4-nitrophenylthio)-1-dethia-2-thia-3-cephem-4-carboxylate (102191-75-3,102191-77-5,124918-24-7)

Guidance literature:

With diphosphorus tetraiodide; In pyridine;

DOI:10.3987/COM-88-S127

upstream raw materials:

tert-butyl 7β-<2-(2-tritylaminothiazol-4-yl)-(Z)-2-methoxyiminoacetamido>-3-<(5-methyl-1,3,4-thiadiazol-2-yl)thio>-4-hydroxy-1-dethia-2-thiacepham-4-carboxylate

tert-butyl 7β-<2-(2-tritylaminothiazol-4-yl)-(Z)-2-methoxyiminoacetamido>-3-(4-nitrophenylthio)-4-hydroxy-1-dethia-2-thiacepham-4-carboxylate

tert-butyl 7β-<2-(2-tritylaminothiazol-4-yl)-(Z)-2-methoxyiminoacetamido>-3-(4-nitrobenzylthio)-4-hydroxy-1-dethia-2-thiacepham-4-carboxylate

tert-butyl diazopyruvate