1-(2,5-Dimethoxyphenyl)piperazine

Base Information

• Chemical Name: 1-(2,5-Dimethoxyphenyl)piperazine
• CAS No.: 1019-06-3
• Molecular Formula: C12H18N2O2
• Molecular Weight: 222.287
• DSSTox Substance ID: DTXSID10374340
• Nikkaji Number: J387.186J
• Wikidata: Q82162889
• ChEMBL ID: CHEMBL156216
• Mol file: 1019-06-3.mol

Synonyms:1-(2,5-dimethoxyphenyl)piperazine;1019-06-3;Piperazine, 1-(2,5-dimethoxyphenyl)-;1-(2,5-Dimethoxy-phenyl)-piperazine;CHEMBL156216;D02SAF;Oprea1_560724;SCHEMBL2349863;DTXSID10374340;IZFHRJZAZNTUOI-UHFFFAOYSA-N;4-[2,5-Dimethoxyphenyl]piperazine;BDBM50226212;GS1441;AKOS003591177;PD178822;CS-0303020;EN300-1852737

Chemical Property of 1-(2,5-Dimethoxyphenyl)piperazine

Chemical Property:

• XLogP3: 1.3
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 3
• Exact Mass: 222.136827821
• Heavy Atom Count: 16
• Complexity: 207

Purity/Quality:

95% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=CC(=C(C=C1)OC)N2CCNCC2

Technology Process of 1-(2,5-Dimethoxyphenyl)piperazine

There total 3 articles about 1-(2,5-Dimethoxyphenyl)piperazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

N,N-bis(chloro-2-ethyl)amine (334-22-5) + 2,5-dimethoxyaniline (102-56-7,102526-87-4) → 1-(2,5-dimethoxyphenyl)piperazine (1019-06-3)

Guidance literature:

N,N-bis(chloro-2-ethyl)amine; 2,5-dimethoxyaniline; at 150 ℃; Inert atmosphere;

With sodium carbonate; Inert atmosphere;

DOI:10.1021/cn500084x

Reference yield: 62.0%

bis-(2-chloroethyl)amine hydrochloride (821-48-7) + 2,5-dimethoxyaniline (102-56-7,102526-87-4) → 1-(2,5-dimethoxyphenyl)piperazine (1019-06-3)

Guidance literature:

With potassium carbonate; In diethylene glycol dimethyl ether; for 48h; Heating;

DOI:10.1021/jm00155a008

Reference yield:

→ 1-(2,5-dimethoxyphenyl)piperazine (1019-06-3)

Guidance literature:

2,5-Dimethoxy-anilin, Bis-<2-brom-ethyl>-amin-hydrobromid, Butan-2-on, 3h, Kochen;

DOI:10.1021/jm00325a021

upstream raw materials:

N,N-bis(chloro-2-ethyl)amine

2,5-dimethoxyaniline

bis-(2-chloroethyl)amine hydrochloride

Downstream raw materials:

2-{4-[4-(2,5-Dimethoxy-phenyl)-piperazin-1-yl]-butyl}-isoindole-1,3-dione

1-(2,5-dimethoxy-4-bromophenyl)piperazine