Technology Process of Benzenepropanamine, 3,5-dichloro-N-(2,2-dimethoxyethyl)-
There total 6 articles about Benzenepropanamine, 3,5-dichloro-N-(2,2-dimethoxyethyl)- which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 6 steps
1: 69 percent / piperidine / 1.) 100 deg C, 2 h, 2.) 155 deg C, 1 h
2: 95 percent / H2 / 10 percent Pd/C / tetrahydrofuran / 5 h / 2585.7 Torr
3: 98 percent / 1 M BH3*THF / tetrahydrofuran / 2 h / Ambient temperature
4: 1.) oxalyl chloride, Me2SO, 2.) NEt3 / 1.) CH2Cl2, -60 deg C, 10 min, 2.) CH2Cl2, -60 deg C, 5 min
5: hexane / 1 h
6: NaBH4 / ethanol / 18 h
With
piperidine; sodium tetrahydroborate; borane-THF; oxalyl dichloride; hydrogen; dimethyl sulfoxide; triethylamine;
palladium on activated charcoal;
In
tetrahydrofuran; ethanol; hexane;
DOI:10.1021/jm00386a008
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 95 percent / H2 / 10 percent Pd/C / tetrahydrofuran / 5 h / 2585.7 Torr
2: 98 percent / 1 M BH3*THF / tetrahydrofuran / 2 h / Ambient temperature
3: 1.) oxalyl chloride, Me2SO, 2.) NEt3 / 1.) CH2Cl2, -60 deg C, 10 min, 2.) CH2Cl2, -60 deg C, 5 min
4: hexane / 1 h
5: NaBH4 / ethanol / 18 h
With
sodium tetrahydroborate; borane-THF; oxalyl dichloride; hydrogen; dimethyl sulfoxide; triethylamine;
palladium on activated charcoal;
In
tetrahydrofuran; ethanol; hexane;
DOI:10.1021/jm00386a008
- Guidance literature:
-
With
sodium tetrahydroborate;
In
ethanol;
for 18h;
Yield given;
DOI:10.1021/jm00386a008
