3-(2-Chlorophenyl)-2-hydroxypropanoic acid

Base Information

• Chemical Name: 3-(2-Chlorophenyl)-2-hydroxypropanoic acid
• CAS No.: 133373-31-6
• Molecular Formula: C₉H₉ClO₃
• Molecular Weight: 200.622
• Mol file: 133373-31-6.mol

Synonyms:

Chemical Property of 3-(2-Chlorophenyl)-2-hydroxypropanoic acid

Chemical Property:

Purity/Quality:

95% ^*data from raw suppliers

3-(2-chlorophenyl)-2-hydroxypropanoicacid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-(2-Chlorophenyl)-2-hydroxypropanoic acid

There total 3 articles about 3-(2-Chlorophenyl)-2-hydroxypropanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

4-(o-chlorophenyl)-2,3-diketobutyramide hydrate (133373-29-2) → rac-3-(2-chlorophenyl)-2-hydroxypropionic acid (133373-31-6)

Guidance literature:

With sulfuric acid; for 1.5h; Heating;

DOI:10.1021/jo00009a029

Reference yield:

rac-2-chlorophenylalanine (14091-11-3,80126-50-7) → rac-3-(2-chlorophenyl)-2-hydroxypropionic acid (133373-31-6)

Guidance literature:

With sulfuric acid; sodium nitrite; at 0 - 20 ℃;

DOI:10.1002/ejoc.200600454

Reference yield:

(S)-3-(2-chlorophenyl)-2-hydroxypropionic acid → rac-3-(2-chlorophenyl)-2-hydroxypropionic acid (133373-31-6)

Guidance literature:

With Lactobacillus paracasei DSM 20207; In water; at 42 ℃; for 24h; pH=6; Further Variations:; Reagents; Product distribution;

DOI:10.1002/ejoc.200600454

upstream raw materials:

4-(o-chlorophenyl)-2,3-diketobutyramide hydrate

rac-2-chlorophenylalanine

Refernces

• 1、 Dahn, Hans,Rotzler, Gerhard. "Unstable 1,1,2-Enetriols as (Probable) Intermediates in the Decarboxylation of α,β-Diketo Acids". . p. 3080 - 3082. Retrieved 2007/10/02.