1-acetyl-5,6-dimethoxy-8-phenyl-2,3,7,8,9,9a-hexahydro-1H-benzoquinoline

Base Information

• Chemical Name: 1-acetyl-5,6-dimethoxy-8-phenyl-2,3,7,8,9,9a-hexahydro-1H-benzoquinoline
• CAS No.: 345939-01-7
• Molecular Formula: C₂₂H₂₅NO₃
• Molecular Weight: 351.445

Synonyms:

Chemical Property of 1-acetyl-5,6-dimethoxy-8-phenyl-2,3,7,8,9,9a-hexahydro-1H-benzoquinoline

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of 1-acetyl-5,6-dimethoxy-8-phenyl-2,3,7,8,9,9a-hexahydro-1H-benzoquinoline

There total 3 articles about 1-acetyl-5,6-dimethoxy-8-phenyl-2,3,7,8,9,9a-hexahydro-1H-benzoquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1,2-diacetoxy-6-acetyl-5,6,6a,7,7a,12a-hexahydro-4H-benzobenzothieno<2,3-g>quinoline (86738-64-9) → 1-acetyl-5,6-dimethoxy-8-phenyl-2,3,7,8,9,9a-hexahydro-1H-benzoquinoline (345939-01-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) aq. NaOH / 1.) acetone, reflux, 1 h, 2.) reflux, 15 min

2: 0.3 g / MeOH, HCl (conc., 2 drops) / Raney Ni (W₂) / 1 h / Heating

With hydrogenchloride; methanol; sodium hydroxide; Raney Ni (W₂);

DOI:10.1039/P19830000909

Reference yield:

1,2-dihydroxy-5,6,6a,7,7a,12a-hexahydro-4H-benzobenzothieno<2,3-g>quinoline hydrobromide (86738-62-7) → 1-acetyl-5,6-dimethoxy-8-phenyl-2,3,7,8,9,9a-hexahydro-1H-benzoquinoline (345939-01-7)

Guidance literature:

Multi-step reaction with 3 steps

1: 1.7 g / pyridine

2: 1.) aq. NaOH / 1.) acetone, reflux, 1 h, 2.) reflux, 15 min

3: 0.3 g / MeOH, HCl (conc., 2 drops) / Raney Ni (W₂) / 1 h / Heating

With pyridine; hydrogenchloride; methanol; sodium hydroxide; Raney Ni (W₂);

DOI:10.1039/P19830000909

Reference yield:

1-(3-benzothienylmethyl)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline (86738-63-8) → 1-acetyl-5,6-dimethoxy-8-phenyl-2,3,7,8,9,9a-hexahydro-1H-benzoquinoline (345939-01-7)

Guidance literature:

Multi-step reaction with 4 steps

1: 1.8 g / HBr / 8 h / Heating

2: 1.7 g / pyridine

3: 1.) aq. NaOH / 1.) acetone, reflux, 1 h, 2.) reflux, 15 min

4: 0.3 g / MeOH, HCl (conc., 2 drops) / Raney Ni (W₂) / 1 h / Heating

With pyridine; hydrogenchloride; methanol; sodium hydroxide; hydrogen bromide; Raney Ni (W₂);

DOI:10.1039/P19830000909

upstream raw materials:

1,2-diacetoxy-6-acetyl-5,6,6a,7,7a,12a-hexahydro-4H-benzobenzothieno<2,3-g>quinoline

1,2-dihydroxy-5,6,6a,7,7a,12a-hexahydro-4H-benzobenzothieno<2,3-g>quinoline hydrobromide

1-(3-benzothienylmethyl)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline

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