Technology Process of sodium 6β-<(D)-2-(4-ethyl-2,3-dioxopiperazin-1-ylcarbonylamino)-2-(3,4-diacetoxyphenyl)acetamido>-6α-formamidopenicillanate 1α-oxide
There total 7 articles about sodium 6β-<(D)-2-(4-ethyl-2,3-dioxopiperazin-1-ylcarbonylamino)-2-(3,4-diacetoxyphenyl)acetamido>-6α-formamidopenicillanate 1α-oxide which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 2 steps
1: 21 percent / DCC / CH2Cl2 / 1) 0 deg C 2) RT, 1 h
2: 1) hydrogen 2) NaHCO3 / 1) 10percent Pd/C / 1) dioxan, 2.5 h 2) H2O
With
hydrogen; sodium hydrogencarbonate; dicyclohexyl-carbodiimide;
palladium on activated charcoal;
In
dichloromethane;
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 83 percent / 5.24percent peracetic acid in AcOH / CH2Cl2 / 1) -10 deg C 2) 0 deg C, 16 h
2: 89 percent / zinc powder, 1M HCl, 1M potassium hydrogen phosphate / tetrahydrofuran; H2O / pH= 4-6
3: 21 percent / DCC / CH2Cl2 / 1) 0 deg C 2) RT, 1 h
4: 1) hydrogen 2) NaHCO3 / 1) 10percent Pd/C / 1) dioxan, 2.5 h 2) H2O
With
hydrogenchloride; peracetic acid; dipotassium hydrogenphosphate; hydrogen; sodium hydrogencarbonate; dicyclohexyl-carbodiimide; zinc;
palladium on activated charcoal;
In
tetrahydrofuran; dichloromethane; water;
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 91 percent / triethylamine, 4-dimethylaminopyridine / CH2Cl2 / 2 h / 0 °C
2: 83 percent / 5.24percent peracetic acid in AcOH / CH2Cl2 / 1) -10 deg C 2) 0 deg C, 16 h
3: 89 percent / zinc powder, 1M HCl, 1M potassium hydrogen phosphate / tetrahydrofuran; H2O / pH= 4-6
4: 21 percent / DCC / CH2Cl2 / 1) 0 deg C 2) RT, 1 h
5: 1) hydrogen 2) NaHCO3 / 1) 10percent Pd/C / 1) dioxan, 2.5 h 2) H2O
With
hydrogenchloride; peracetic acid; dmap; dipotassium hydrogenphosphate; hydrogen; sodium hydrogencarbonate; triethylamine; dicyclohexyl-carbodiimide; zinc;
palladium on activated charcoal;
In
tetrahydrofuran; dichloromethane; water;
