[2-(4-{4-[3-(3,4-difluoro-phenoxymethyl)-[1,2,4]oxadiazol-5-yl]-benzenesulfonylamino}-phenyl)-ethyl]-(2-hydroxy-2-pyridin-3-yl-ethyl)-carbamic acid tert-butyl ester

Base Information

Chemical Name:[2-(4-{4-[3-(3,4-difluoro-phenoxymethyl)-[1,2,4]oxadiazol-5-yl]-benzenesulfonylamino}-phenyl)-ethyl]-(2-hydroxy-2-pyridin-3-yl-ethyl)-carbamic acid tert-butyl ester
CAS No.:294843-46-2
Molecular Formula:C₃₅H₃₅F₂N₅O₇S
Molecular Weight:707.755
Hs Code.:

[2-(4-{4-[3-(3,4-difluoro-phenoxymethyl)-[1,2,4]oxadiazol-5-yl]-benzenesulfonylamino}-phenyl)-ethyl]-(2-hydroxy-2-pyridin-3-yl-ethyl)-carbamic acid <i>tert</i>-butyl ester

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Chemical Property of [2-(4-{4-[3-(3,4-difluoro-phenoxymethyl)-[1,2,4]oxadiazol-5-yl]-benzenesulfonylamino}-phenyl)-ethyl]-(2-hydroxy-2-pyridin-3-yl-ethyl)-carbamic acid tert-butyl ester

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Technology Process of [2-(4-{4-[3-(3,4-difluoro-phenoxymethyl)-[1,2,4]oxadiazol-5-yl]-benzenesulfonylamino}-phenyl)-ethyl]-(2-hydroxy-2-pyridin-3-yl-ethyl)-carbamic acid tert-butyl ester

There total 4 articles about [2-(4-{4-[3-(3,4-difluoro-phenoxymethyl)-[1,2,4]oxadiazol-5-yl]-benzenesulfonylamino}-phenyl)-ethyl]-(2-hydroxy-2-pyridin-3-yl-ethyl)-carbamic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 10130-89-9
p-carboxyphenylsulfonyl chloride

: 294843-46-2
[2-(4-{4-[3-(3,4-difluoro-phenoxymethyl)-[1,2,4]oxadiazol-5-yl]-benzenesulfonylamino}-phenyl)-ethyl]-(2-hydroxy-2-pyridin-3-yl-ethyl)-carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: pyridine / 20 °C

2: EDC / bis-(2-methoxy-ethyl) ether / 20 °C

3: 4 h / 100 °C

With pyridine; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; In diethylene glycol dimethyl ether; 1: Sulfonylation / 2: Condensation / 3: Cyclization;
DOI:10.1016/S0960-894X(00)00268-7

Reference yield:

: 173901-05-8
(R)-N-[2-(4-aminophenyl)ethyl]-2-hydroxy-2-(3-pyridyl)ethylcarbamic acid 1,1-dimethylethyl ester

: 294843-46-2
[2-(4-{4-[3-(3,4-difluoro-phenoxymethyl)-[1,2,4]oxadiazol-5-yl]-benzenesulfonylamino}-phenyl)-ethyl]-(2-hydroxy-2-pyridin-3-yl-ethyl)-carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: pyridine / 20 °C

2: EDC / bis-(2-methoxy-ethyl) ether / 20 °C

3: 4 h / 100 °C

With pyridine; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; In diethylene glycol dimethyl ether; 1: Sulfonylation / 2: Condensation / 3: Cyclization;
DOI:10.1016/S0960-894X(00)00268-7

Reference yield:

: 4-(4-{2-[tert-butoxycarbonyl-(2-hydroxy-2-pyridin-3-yl-ethyl)-amino]-ethyl}-phenylsulfamoyl)-benzoic acid

: 294843-46-2
[2-(4-{4-[3-(3,4-difluoro-phenoxymethyl)-[1,2,4]oxadiazol-5-yl]-benzenesulfonylamino}-phenyl)-ethyl]-(2-hydroxy-2-pyridin-3-yl-ethyl)-carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: EDC / bis-(2-methoxy-ethyl) ether / 20 °C

2: 4 h / 100 °C

With N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; In diethylene glycol dimethyl ether; 1: Condensation / 2: Cyclization;
DOI:10.1016/S0960-894X(00)00268-7