(2R,3R)-3-Benzyloxy-2-[(4S,5R)-5-(tert-butyl-dimethyl-silanyloxymethyl)-2,2-dimethyl-[1,3]dioxolan-4-yl]-cyclopentanone

Base Information

Chemical Name:(2R,3R)-3-Benzyloxy-2-[(4S,5R)-5-(tert-butyl-dimethyl-silanyloxymethyl)-2,2-dimethyl-[1,3]dioxolan-4-yl]-cyclopentanone
CAS No.:159656-61-8
Molecular Formula:C₂₄H₃₈O₅Si
Molecular Weight:434.648
Hs Code.:

Synonyms:

Suppliers and Price of (2R,3R)-3-Benzyloxy-2-[(4S,5R)-5-(tert-butyl-dimethyl-silanyloxymethyl)-2,2-dimethyl-[1,3]dioxolan-4-yl]-cyclopentanone

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (2R,3R)-3-Benzyloxy-2-[(4S,5R)-5-(tert-butyl-dimethyl-silanyloxymethyl)-2,2-dimethyl-[1,3]dioxolan-4-yl]-cyclopentanone

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (2R,3R)-3-Benzyloxy-2-[(4S,5R)-5-(tert-butyl-dimethyl-silanyloxymethyl)-2,2-dimethyl-[1,3]dioxolan-4-yl]-cyclopentanone

There total 15 articles about (2R,3R)-3-Benzyloxy-2-[(4S,5R)-5-(tert-butyl-dimethyl-silanyloxymethyl)-2,2-dimethyl-[1,3]dioxolan-4-yl]-cyclopentanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 159656-60-7
(1R,2R,3R)-3-benzyloxy-2-<(1'S,2'R)-3'-(tert-butyldimethylsiloxy)-1',2'-(isopropylidenedioxy)propyl>cyclopentanol

: 159656-61-8
(2R,3R)-3-Benzyloxy-2-[(4S,5R)-5-(tert-butyl-dimethyl-silanyloxymethyl)-2,2-dimethyl-[1,3]dioxolan-4-yl]-cyclopentanone

Guidance literature:: With tetrapropylammonium perruthennate; 4 A molecular sieve; 4-methylmorpholine N-oxide; In dichloromethane; for 0.5h; Ambient temperature;

Reference yield:

: 144708-87-2
(2R)-6-hydroxy-2-<4'-(trimethylsilyl)but-3'-ynyl>-3,6-dihydropyran-3(2H)-one

: 159656-61-8
(2R,3R)-3-Benzyloxy-2-[(4S,5R)-5-(tert-butyl-dimethyl-silanyloxymethyl)-2,2-dimethyl-[1,3]dioxolan-4-yl]-cyclopentanone

Guidance literature:: Multi-step reaction with 13 steps

1: 62 percent / pyridinium toluene-p-sulfonate / CH₂Cl₂ / 5 h / Ambient temperature

2: 92 percent / LAH / diethyl ether / 0 °C

3: 70 percent / pyridine, osmium tetraoxide / diethyl ether / 10 h / Ambient temperature

4: 74 percent / PPTS / dimethylformamide; acetone / 10 h / Ambient temperature

5: 68 percent / DMAP / 1,2-dichloro-ethane / 5 h / Heating

6: 92 percent / Bu₃SnH, AIBN / benzene / 0.5 h / Heating

7: 86 percent / pyridine, NaIO₄, osmium tetraoxide / 2-methyl-propan-2-ol; H₂O / 4.5 h / Ambient temperature

8: 55 percent / Na / tetrahydrofuran; ethanol; liquid ammonia / 1.) -78 deg C, 20 min, 2.) room temperature, 1 h

9: 98 percent / NaH, Bu₄NI / tetrahydrofuran; paraffin / 15 h / Ambient temperature

10: 98 percent / HCl / tetrahydrofuran / 2 h / Ambient temperature

11: 100 percent / NaBH₄ / methanol; CH₂Cl₂ / 1 h / Ambient temperature

12: 100 percent / DMAP / CH₂Cl₂ / 10 h / Ambient temperature

13: 4-methylmorpholine N-oxide, molecular sieves 4 A, tetrapropylammonium perruthenate / CH₂Cl₂ / 0.5 h / Ambient temperature

With pyridine; hydrogenchloride; dmap; sodium tetrahydroborate; sodium periodate; osmium(VIII) oxide; lithium aluminium tetrahydride; tetrapropylammonium perruthennate; 2,2'-azobis(isobutyronitrile); 4 A molecular sieve; tri-n-butyl-tin hydride; sodium; pyridinium p-toluenesulfonate; tetra-(n-butyl)ammonium iodide; sodium hydride; 4-methylmorpholine N-oxide; In tetrahydrofuran; methanol; diethyl ether; ethanol; dichloromethane; ammonia; water; 1,2-dichloro-ethane; N,N-dimethyl-formamide; acetone; paraffin; tert-butyl alcohol; benzene;

Reference yield:

: (2R,6R)-6-(1-ethoxyethoxy)-2-<4'-(trimethylsilyl)but-3'-ynyl>-3,6-dihydropyran-3(2H)-one

: 159656-61-8
(2R,3R)-3-Benzyloxy-2-[(4S,5R)-5-(tert-butyl-dimethyl-silanyloxymethyl)-2,2-dimethyl-[1,3]dioxolan-4-yl]-cyclopentanone

Guidance literature:: Multi-step reaction with 12 steps

1: 92 percent / LAH / diethyl ether / 0 °C

2: 70 percent / pyridine, osmium tetraoxide / diethyl ether / 10 h / Ambient temperature

3: 74 percent / PPTS / dimethylformamide; acetone / 10 h / Ambient temperature

4: 68 percent / DMAP / 1,2-dichloro-ethane / 5 h / Heating

5: 92 percent / Bu₃SnH, AIBN / benzene / 0.5 h / Heating

6: 86 percent / pyridine, NaIO₄, osmium tetraoxide / 2-methyl-propan-2-ol; H₂O / 4.5 h / Ambient temperature

7: 55 percent / Na / tetrahydrofuran; ethanol; liquid ammonia / 1.) -78 deg C, 20 min, 2.) room temperature, 1 h

8: 98 percent / NaH, Bu₄NI / tetrahydrofuran; paraffin / 15 h / Ambient temperature

9: 98 percent / HCl / tetrahydrofuran / 2 h / Ambient temperature

10: 100 percent / NaBH₄ / methanol; CH₂Cl₂ / 1 h / Ambient temperature

11: 100 percent / DMAP / CH₂Cl₂ / 10 h / Ambient temperature

12: 4-methylmorpholine N-oxide, molecular sieves 4 A, tetrapropylammonium perruthenate / CH₂Cl₂ / 0.5 h / Ambient temperature

With pyridine; hydrogenchloride; dmap; sodium tetrahydroborate; sodium periodate; osmium(VIII) oxide; lithium aluminium tetrahydride; tetrapropylammonium perruthennate; 2,2'-azobis(isobutyronitrile); 4 A molecular sieve; tri-n-butyl-tin hydride; sodium; pyridinium p-toluenesulfonate; tetra-(n-butyl)ammonium iodide; sodium hydride; 4-methylmorpholine N-oxide; In tetrahydrofuran; methanol; diethyl ether; ethanol; dichloromethane; ammonia; water; 1,2-dichloro-ethane; N,N-dimethyl-formamide; acetone; paraffin; tert-butyl alcohol; benzene;