Technology Process of 5-hydroxycytidine
There total 6 articles about 5-hydroxycytidine which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
CYTIDINE;
With
water; bromine;
at 0 ℃;
With
2,4,6-trimethyl-pyridine;
at 40 ℃;
for 2h;
DOI:10.1093/nar/gkr673
- Guidance literature:
-
With
sodium hydroxide;
at 90.1 ℃;
Rate constant;
Mechanism;
various reagent concentration;
- Guidance literature:
-
Multi-step reaction with 2 steps
1: adenylate kinase; CTP synthetase; dATP; kanamycin; creatine phosphate; DL-dithiothreitol; ampicillin; ammonium chloride; 2'-deoxyadenosine-5'-monophosphoric acid; creatine phosphokinase / water / 24 h / pH 8.5 / Enzymatic reaction
2: calf intestinal alkaline phosphatase; zinc acetate dehydrate; magnesium chloride / water / 24 h / pH 9.5 / Enzymatic reaction
With
calf intestinal alkaline phosphatase; adenylate kinase; DL-dithiothreitol; zinc acetate dehydrate; CTP synthetase; creatine phosphate; dATP; kanamycin; ampicillin; ammonium chloride; 2'-deoxyadenosine-5'-monophosphoric acid; magnesium chloride; creatine phosphokinase;
In
water;
DOI:10.1007/s13361-011-0126-8