1H-Pyrrole-3-carboxamide, 2,5-dihydro-N-[3-[[[2-methoxy-4-(1-propenyl)phenoxy]acetyl]amino]-2,2- dimethylpropyl]-2,2,5,5-tetramethyl-

Base Information

• Chemical Name: 1H-Pyrrole-3-carboxamide, 2,5-dihydro-N-[3-[[[2-methoxy-4-(1-propenyl)phenoxy]acetyl]amino]-2,2- dimethylpropyl]-2,2,5,5-tetramethyl-
• CAS No.: 102131-53-3
• Molecular Formula: C₂₆H₃₉N₃O₄
• Molecular Weight: 457.613
• Mol file: 102131-53-3.mol

Synonyms:

Chemical Property of 1H-Pyrrole-3-carboxamide, 2,5-dihydro-N-[3-[[[2-methoxy-4-(1-propenyl)phenoxy]acetyl]amino]-2,2- dimethylpropyl]-2,2,5,5-tetramethyl-

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1H-Pyrrole-3-carboxamide, 2,5-dihydro-N-[3-[[[2-methoxy-4-(1-propenyl)phenoxy]acetyl]amino]-2,2- dimethylpropyl]-2,2,5,5-tetramethyl-

There total 4 articles about 1H-Pyrrole-3-carboxamide, 2,5-dihydro-N-[3-[[[2-methoxy-4-(1-propenyl)phenoxy]acetyl]amino]-2,2- dimethylpropyl]-2,2,5,5-tetramethyl- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2,2-Dimethyl-1,3-diaminopropane (7328-91-8) → 2,2,5,5-Tetramethyl-2,5-dihydro-1H-pyrrole-3-carboxylic acid (3-{2-[2-methoxy-4-((E)-propenyl)-phenoxy]-acetylamino}-2,2-dimethyl-propyl)-amide (102131-53-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 79 percent / K₂CO₃ / H₂O / 3 h / 25 °C

2: CHCl₃ / 3 h / Heating

With potassium carbonate; In chloroform; water;

DOI:10.1021/jm00157a005

Reference yield:

(2-methoxy-4-propenyl-phenoxy)-acetic acid (7510-46-5) → 2,2,5,5-Tetramethyl-2,5-dihydro-1H-pyrrole-3-carboxylic acid (3-{2-[2-methoxy-4-((E)-propenyl)-phenoxy]-acetylamino}-2,2-dimethyl-propyl)-amide (102131-53-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 84 percent / N,N'-dicyclohexylcarbodiimide / ethyl acetate

2: CHCl₃ / 3 h / Heating

With dicyclohexyl-carbodiimide; In chloroform; ethyl acetate;

DOI:10.1021/jm00157a005

Reference yield:

3,5-Dibromo-4-oxo-2,2,6,6-tetramethylpiperidine Hydrobromide (19971-12-1) → 2,2,5,5-Tetramethyl-2,5-dihydro-1H-pyrrole-3-carboxylic acid (3-{2-[2-methoxy-4-((E)-propenyl)-phenoxy]-acetylamino}-2,2-dimethyl-propyl)-amide (102131-53-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 79 percent / K₂CO₃ / H₂O / 3 h / 25 °C

2: CHCl₃ / 3 h / Heating

With potassium carbonate; In chloroform; water;

DOI:10.1021/jm00157a005

upstream raw materials:

2,2,5,5-Tetramethyl-2,5-dihydro-1H-pyrrole-3-carboxylic acid (3-amino-2,2-dimethyl-propyl)-amide

[2-Methoxy-4-((E)-propenyl)-phenoxy]-acetic acid 2,5-dioxo-pyrrolidin-1-yl ester

2,2-Dimethyl-1,3-diaminopropane

(2-methoxy-4-propenyl-phenoxy)-acetic acid