1H-Pyrazole-4-carboxaldehyde, 3-iodo-1-(tetrahydro-2H-pyran-2-yl)-

Base Information

• Chemical Name: 1H-Pyrazole-4-carboxaldehyde, 3-iodo-1-(tetrahydro-2H-pyran-2-yl)-
• CAS No.: 1627924-19-9
• Molecular Formula: C₉H₁₁IN₂O₂
• Molecular Weight: 306.103
• Hs Code.: 2933199090
• Mol file: 1627924-19-9.mol

Synonyms:

Chemical Property of 1H-Pyrazole-4-carboxaldehyde, 3-iodo-1-(tetrahydro-2H-pyran-2-yl)-

Chemical Property:

• Boiling Point: 416.4±45.0 °C(Predicted)
• PKA: -2.14±0.19(Predicted)
• Density: 1.94±0.1 g/cm3(Predicted)

Purity/Quality:

97% ^*data from raw suppliers

3-Iodo-1-(tetrahydropyran-2-yl)-1H-pyrazole-4-carbaldehyde 95%+ ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1H-Pyrazole-4-carboxaldehyde, 3-iodo-1-(tetrahydro-2H-pyran-2-yl)-

There total 3 articles about 1H-Pyrazole-4-carboxaldehyde, 3-iodo-1-(tetrahydro-2H-pyran-2-yl)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

(rac)-(3-iodo-1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazol-4-yl)methanol → 3-iodo-1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazole-4-carbaldehyde (1627924-19-9)

Guidance literature:

(rac)-(3-iodo-1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazol-4-yl)methanol; With oxalyl dichloride; dimethyl sulfoxide; In dichloromethane; at -65 ℃; for 1h; Inert atmosphere;

With triethylamine; In dichloromethane; at 65 ℃; for 0.5h; Inert atmosphere;

Reference yield:

(rac)-ethyl 3-iodo-1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazole-4-carboxylate (1190060-37-7) → 3-iodo-1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazole-4-carbaldehyde (1627924-19-9)

Guidance literature:

Multi-step reaction with 3 steps

1.1: lithium hydroxide; water / tetrahydrofuran; methanol / 20 °C

2.1: diborane / tetrahydrofuran / 5 - 20 °C / Inert atmosphere

3.1: oxalyl dichloride; dimethyl sulfoxide / dichloromethane / 1 h / -65 °C / Inert atmosphere

3.2: 0.5 h / 65 °C / Inert atmosphere

With oxalyl dichloride; water; dimethyl sulfoxide; diborane; lithium hydroxide; In tetrahydrofuran; methanol; dichloromethane;

Reference yield:

3-iodo-1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazole-4-carboxylic acid → 3-iodo-1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazole-4-carbaldehyde (1627924-19-9)

Guidance literature:

Multi-step reaction with 2 steps

1.1: diborane / tetrahydrofuran / 5 - 20 °C / Inert atmosphere

2.1: oxalyl dichloride; dimethyl sulfoxide / dichloromethane / 1 h / -65 °C / Inert atmosphere

2.2: 0.5 h / 65 °C / Inert atmosphere

With oxalyl dichloride; dimethyl sulfoxide; diborane; In tetrahydrofuran; dichloromethane;

upstream raw materials:

(rac)-ethyl 3-iodo-1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazole-4-carboxylate