(4aS,9aR)-9a-Methoxy-1,2,3,4,4a,9a-hexahydro-fluoren-9-one O-{3-[2-(3,5-dimethoxy-phenyl)-ethylamino]-2-hydroxy-propyl}-oxime

Base Information

• Chemical Name: (4aS,9aR)-9a-Methoxy-1,2,3,4,4a,9a-hexahydro-fluoren-9-one O-{3-[2-(3,5-dimethoxy-phenyl)-ethylamino]-2-hydroxy-propyl}-oxime
• CAS No.: 118017-72-4
• Molecular Formula: C₂₇H₃₆N₂O₅
• Molecular Weight: 468.593
• Mol file: 118017-72-4.mol

Synonyms:

Chemical Property of (4aS,9aR)-9a-Methoxy-1,2,3,4,4a,9a-hexahydro-fluoren-9-one O-{3-[2-(3,5-dimethoxy-phenyl)-ethylamino]-2-hydroxy-propyl}-oxime

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (4aS,9aR)-9a-Methoxy-1,2,3,4,4a,9a-hexahydro-fluoren-9-one O-{3-[2-(3,5-dimethoxy-phenyl)-ethylamino]-2-hydroxy-propyl}-oxime

There total 3 articles about (4aS,9aR)-9a-Methoxy-1,2,3,4,4a,9a-hexahydro-fluoren-9-one O-{3-[2-(3,5-dimethoxy-phenyl)-ethylamino]-2-hydroxy-propyl}-oxime which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(4bR,9aS)-5,5-Dimethoxy-5,6,7,8,9,9a-hexahydro-benzo[3,4]cyclobuta[1,2]cyclohepten-4b-ol (89874-27-1,100703-72-8) → (4aS,9aR)-9a-Methoxy-1,2,3,4,4a,9a-hexahydro-fluoren-9-one O-{3-[2-(3,5-dimethoxy-phenyl)-ethylamino]-2-hydroxy-propyl}-oxime (118017-72-4)

Guidance literature:

Multi-step reaction with 4 steps

1: 61 percent / Me₃SiCl / acetonitrile

2: 91 percent / NH₂OH*HCl, pyridine / ethanol / 1.2 h / Heating

3: NaH / dimethylformamide / 2 h / 20 °C

4: ethanol / 4 h / Heating

With pyridine; chloro-trimethyl-silane; hydroxylamine hydrochloride; sodium hydride; In ethanol; N,N-dimethyl-formamide; acetonitrile;

DOI:10.1021/jm00122a008

Reference yield:

cis-9a-methoxy-1,2,3,4,4a,9a-hexahydrofluoren-9-one (116823-05-3) → (4aS,9aR)-9a-Methoxy-1,2,3,4,4a,9a-hexahydro-fluoren-9-one O-{3-[2-(3,5-dimethoxy-phenyl)-ethylamino]-2-hydroxy-propyl}-oxime (118017-72-4)

Guidance literature:

Multi-step reaction with 3 steps

1: 91 percent / NH₂OH*HCl, pyridine / ethanol / 1.2 h / Heating

2: NaH / dimethylformamide / 2 h / 20 °C

3: ethanol / 4 h / Heating

With pyridine; hydroxylamine hydrochloride; sodium hydride; In ethanol; N,N-dimethyl-formamide;

DOI:10.1021/jm00122a008

Reference yield:

(4aS,9aR)-9a-Methoxy-1,2,3,4,4a,9a-hexahydro-fluoren-9-one oxime (118017-64-4) → (4aS,9aR)-9a-Methoxy-1,2,3,4,4a,9a-hexahydro-fluoren-9-one O-{3-[2-(3,5-dimethoxy-phenyl)-ethylamino]-2-hydroxy-propyl}-oxime (118017-72-4)

Guidance literature:

Multi-step reaction with 2 steps

1: NaH / dimethylformamide / 2 h / 20 °C

2: ethanol / 4 h / Heating

With sodium hydride; In ethanol; N,N-dimethyl-formamide;

DOI:10.1021/jm00122a008

upstream raw materials:

(4bR,9aS)-5,5-Dimethoxy-5,6,7,8,9,9a-hexahydro-benzo[3,4]cyclobuta[1,2]cyclohepten-4b-ol

cis-9a-methoxy-1,2,3,4,4a,9a-hexahydrofluoren-9-one

(4aS,9aR)-9a-Methoxy-1,2,3,4,4a,9a-hexahydro-fluoren-9-one oxime