3-[3-((1S)-2-{[2-(2,3-dihydro-1H-inden-2-yl)-1,1-dimethylethyl]amino}-hydroxyethyl)-4,5-difluorophenyl]propanoic acid trifluoroacetate salt

Base Information

Chemical Name:3-[3-((1S)-2-{[2-(2,3-dihydro-1H-inden-2-yl)-1,1-dimethylethyl]amino}-hydroxyethyl)-4,5-difluorophenyl]propanoic acid trifluoroacetate salt
CAS No.:1035154-09-6
Molecular Formula:C₂HF₃O₂*C₂₄H₂₉F₂NO₃
Molecular Weight:531.52
Hs Code.:

3-[3-((1S)-2-{[2-(2,3-dihydro-1H-inden-2-yl)-1,1-dimethylethyl]amino}-hydroxyethyl)-4,5-difluorophenyl]propanoic acid trifluoroacetate salt

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Chemical Property of 3-[3-((1S)-2-{[2-(2,3-dihydro-1H-inden-2-yl)-1,1-dimethylethyl]amino}-hydroxyethyl)-4,5-difluorophenyl]propanoic acid trifluoroacetate salt

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Technology Process of 3-[3-((1S)-2-{[2-(2,3-dihydro-1H-inden-2-yl)-1,1-dimethylethyl]amino}-hydroxyethyl)-4,5-difluorophenyl]propanoic acid trifluoroacetate salt

There total 13 articles about 3-[3-((1S)-2-{[2-(2,3-dihydro-1H-inden-2-yl)-1,1-dimethylethyl]amino}-hydroxyethyl)-4,5-difluorophenyl]propanoic acid trifluoroacetate salt which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 5-bromo-2,3-difluoro-phenol

: 1035154-09-6
3-[3-((1S)-2-{[2-(2,3-dihydro-1H-inden-2-yl)-1,1-dimethylethyl]amino}-hydroxyethyl)-4,5-difluorophenyl]propanoic acid trifluoroacetate salt

Guidance literature:: Multi-step reaction with 10 steps

1.1: propiononitrile / 0.25 h / 120 °C

1.2: 22 h / 20 °C

2.1: hydrogen / 5% palladium over charcoal / ethanol / 42.5 h / 2844.39 Torr

2.2: 0.5 h / 3102.97 Torr

3.1: triethylamine / dichloromethane / 0 - 20 °C

4.1: lithium chloride / bis(tributylphosphine) palladium / N,N-dimethyl-formamide / 22 h / 20 °C

4.2: 2 h / 20 °C

5.1: AD-mix-α / water; tert-butyl alcohol / 0 - 20 °C

5.2: 5 h / 20 °C

6.1: pyridine / 4.62 h / -20 - -10 °C

7.1: sodium iodide / acetone / 18 h / Heating / reflux

8.1: potassium carbonate / ethanol / 17 h / 90 °C

9.1: sodium hydroxide; water / ethanol / 28 h / 20 °C

With pyridine; sodium hydroxide; AD-mix-α; water; hydrogen; potassium carbonate; triethylamine; sodium iodide; lithium chloride; bis(tributylphosphine) palladium; 5% palladium over charcoal; In ethanol; dichloromethane; water; N,N-dimethyl-formamide; acetone; propiononitrile; tert-butyl alcohol; 4.1: Curtius Rearrangement;

Reference yield:

: 1035154-96-1
ethyl (2E)-3-(3,4-difluoro-5-hydroxyphenyl)-2-propenoate

: 1035154-09-6
3-[3-((1S)-2-{[2-(2,3-dihydro-1H-inden-2-yl)-1,1-dimethylethyl]amino}-hydroxyethyl)-4,5-difluorophenyl]propanoic acid trifluoroacetate salt

Guidance literature:: Multi-step reaction with 9 steps

1.1: hydrogen / 5% palladium over charcoal / ethanol / 42.5 h / 2844.39 Torr

1.2: 0.5 h / 3102.97 Torr

2.1: triethylamine / dichloromethane / 0 - 20 °C

3.1: lithium chloride / bis(tributylphosphine) palladium / N,N-dimethyl-formamide / 22 h / 20 °C

3.2: 2 h / 20 °C

4.1: AD-mix-α / water; tert-butyl alcohol / 0 - 20 °C

4.2: 5 h / 20 °C

5.1: pyridine / 4.62 h / -20 - -10 °C

6.1: sodium iodide / acetone / 18 h / Heating / reflux

7.1: potassium carbonate / ethanol / 17 h / 90 °C

8.1: sodium hydroxide; water / ethanol / 28 h / 20 °C

With pyridine; sodium hydroxide; AD-mix-α; water; hydrogen; potassium carbonate; triethylamine; sodium iodide; lithium chloride; bis(tributylphosphine) palladium; 5% palladium over charcoal; In ethanol; dichloromethane; water; N,N-dimethyl-formamide; acetone; tert-butyl alcohol; 3.1: Curtius Rearrangement;

Reference yield:

: 1035154-98-3
ethyl 3-(3,4-difluoro-5-hydroxyphenyl)propanoate

: 1035154-09-6
3-[3-((1S)-2-{[2-(2,3-dihydro-1H-inden-2-yl)-1,1-dimethylethyl]amino}-hydroxyethyl)-4,5-difluorophenyl]propanoic acid trifluoroacetate salt

Guidance literature:: Multi-step reaction with 8 steps

1.1: triethylamine / dichloromethane / 0 - 20 °C

2.1: lithium chloride / bis(tributylphosphine) palladium / N,N-dimethyl-formamide / 22 h / 20 °C

2.2: 2 h / 20 °C

3.1: AD-mix-α / water; tert-butyl alcohol / 0 - 20 °C

3.2: 5 h / 20 °C

4.1: pyridine / 4.62 h / -20 - -10 °C

5.1: sodium iodide / acetone / 18 h / Heating / reflux

6.1: potassium carbonate / ethanol / 17 h / 90 °C

7.1: sodium hydroxide; water / ethanol / 28 h / 20 °C

With pyridine; sodium hydroxide; AD-mix-α; water; potassium carbonate; triethylamine; sodium iodide; lithium chloride; bis(tributylphosphine) palladium; In ethanol; dichloromethane; water; N,N-dimethyl-formamide; acetone; tert-butyl alcohol; 2.1: Curtius Rearrangement;