1-Pyrrolidinecarboxylic acid, 2-[[(1-methylethyl)[[(phenylmethyl)thio]carbonyl]amino]acetyl]-, 1,1-dimethylethyl ester, (S)-

Base Information

Chemical Name:1-Pyrrolidinecarboxylic acid, 2-[[(1-methylethyl)[[(phenylmethyl)thio]carbonyl]amino]acetyl]-, 1,1-dimethylethyl ester, (S)-
CAS No.:102284-47-9
Molecular Formula:C22H32N2O4S
Molecular Weight:420.573
Hs Code.:
Mol file:102284-47-9.mol

Synonyms:

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1-Pyrrolidinecarboxylic acid, 2-[[(1-methylethyl)[[(phenylmethyl)thio]carbonyl]amino]acetyl]-, 1,1-dimethylethyl ester, (S)-

Chemical Property:

Purity/Quality:

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MSDS Files:: SDS file from LookChem

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Technology Process of 1-Pyrrolidinecarboxylic acid, 2-[[(1-methylethyl)[[(phenylmethyl)thio]carbonyl]amino]acetyl]-, 1,1-dimethylethyl ester, (S)-

There total 4 articles about 1-Pyrrolidinecarboxylic acid, 2-[[(1-methylethyl)[[(phenylmethyl)thio]carbonyl]amino]acetyl]-, 1,1-dimethylethyl ester, (S)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 37734-45-5
benzyl chlorothioformate

: 102284-42-4
N-<(N-boc-L-propyl)methyl>isopropylamine

: 102284-47-9
S-benzyl N-<(N-boc-L-prolyl)methyl>-N-isopropylthiocarbamate

Guidance literature:: With triethylamine; In tetrahydrofuran; at 5 ℃; for 2h;
DOI:10.1021/jm00158a025

Reference yield:

: 102284-41-3
N-boc-L-prolyl chloromethyl ketone

: 102284-47-9
S-benzyl N-<(N-boc-L-prolyl)methyl>-N-isopropylthiocarbamate

Guidance literature:: Multi-step reaction with 2 steps

1: 56 percent / sodium iodide / aq. ethanol / 15 h / 65 °C

2: 75 percent / Et₃N / tetrahydrofuran / 2 h / 5 °C

With triethylamine; sodium iodide; In tetrahydrofuran; ethanol;
DOI:10.1021/jm00158a025

Reference yield:

: 101130-03-4
2,2-Dimethyl-propionic acid (S)-2-(2-diazo-acetyl)-pyrrolidin-1-yl ester

: 102284-47-9
S-benzyl N-<(N-boc-L-prolyl)methyl>-N-isopropylthiocarbamate

Guidance literature:: Multi-step reaction with 3 steps

1: 51.7 percent / HCl

2: 56 percent / sodium iodide / aq. ethanol / 15 h / 65 °C

3: 75 percent / Et₃N / tetrahydrofuran / 2 h / 5 °C

With hydrogenchloride; triethylamine; sodium iodide; In tetrahydrofuran; ethanol;
DOI:10.1021/jm00158a025