FFN102

Base Information

• Chemical Name: FFN102
• CAS No.: 1234064-11-9
• Molecular Formula: C₂HF₃O₂*C₁₁H₁₀ClNO₃
• Molecular Weight: 353.682
• Mol file: 1234064-11-9.mol

Synonyms:

Chemical Property of FFN102

Chemical Property:

Purity/Quality:

95%-98% ^*data from raw suppliers

FFN-102 (trifluoroacetate salt) ≥98% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Description: FFN-102 is a fluorescent false neurotransmitter (FFN) that is a substrate for the dopamine transporter (DAT) and vesicular monoamine transporter 2 (VMAT2). It is a pH-dependent fluorescent probe that labels dopamine cell bodies, axons, and presynaptic terminals. It can also be used to monitor dopamine exocytosis. It has a pKa of 6.2 and displays pH-dependent excitation spectra of 340 and 370 nm at pH 5 and 7.4, respectively, which correspond to vesicular and cytoplasmic pH values. The emission spectrum of FFN-102 is pH-independent at 453 nm, but the intensity of emission is pH-dependent with a higher intensity at a pH of 7.4. FFN-102 inhibits DAT (13.6% at a concentration of 10 μM) and the serotonin (5-HT) receptor subtype 5-HT2c (Ki = ~3 μM) but does not bind to 37 other central nervous system receptors and transporters, including dopamine receptors, up to a concentration of 10 μM.

Technology Process of FFN102

There total 1 articles about FFN102 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 37.0%

4-Chlororesorcinol (95-88-5) + 5-((tert-butoxycarbonyl)amino)-3-oxopentanoic acid methyl ester (141734-32-9) + trifluoroacetic acid (76-05-1) → Mini102 (1234064-11-9)

Guidance literature:

4-Chlororesorcinol; 5-((tert-butoxycarbonyl)amino)-3-oxopentanoic acid methyl ester; With methanesulfonic acid; at 0 - 20 ℃;

trifluoroacetic acid; In water; acetonitrile; RP-HPLC;

DOI:10.1021/ja101740k

upstream raw materials:

4-Chlororesorcinol

5-((tert-butoxycarbonyl)amino)-3-oxopentanoic acid methyl ester

trifluoroacetic acid