C₂₈H₃₈N₂O₄

Base Information

Chemical Name:C₂₈H₃₈N₂O₄
CAS No.:1404377-68-9
Molecular Formula:C₂₈H₃₈N₂O₄
Molecular Weight:466.621
Hs Code.:

C<sub>28</sub>H<sub>38</sub>N<sub>2</sub>O<sub>4</sub>

Synonyms:

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Chemical Property of C₂₈H₃₈N₂O₄

Chemical Property:

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Technology Process of C₂₈H₃₈N₂O₄

There total 26 articles about C₂₈H₃₈N₂O₄ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 646-07-1
4-Methylpentanoic acid

: 1404377-68-9
C₂₈H₃₈N₂O₄

Guidance literature:: Multi-step reaction with 21 steps

1.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 20 °C

2.1: 1,1,3,3-Tetramethyldisiloxane / (Ph₃P)2IrCl(CO) / toluene / 2 h / 20 °C

3.1: hydroquinone / acetonitrile / 95 °C

4.1: methyl p-toluene sulfonate / water / 2 h / 110 °C

4.2: 4 h / 95 °C

5.1: hydrogen / rhodium contaminated with carbon / tetrahydrofuran / 7 h / 20 °C / 760.05 Torr

6.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 20 °C

7.1: diisobutylaluminium hydride / dichloromethane / 2 h / -78 °C

7.2: Cooling with ice

8.1: triphenylphosphine / dichloromethane / 0.33 h / Cooling with ice

8.2: 0.33 h / Cooling with ice

9.1: n-butyllithium / hexane; tetrahydrofuran / -78 °C

9.2: 1 h / Cooling with ice

10.1: pyridine / methanol / 20 °C

11.1: iodine / acetonitrile / 3 h

12.1: potassium phosphate / bis-triphenylphosphine-palladium(II) chloride / N,N-dimethyl-formamide; water / 80 °C / Inert atmosphere

13.1: trifluoroacetic acid / chloroform

14.1: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / chloroform

15.1: lithium hexamethyldisilazane / N,N,N,N,N,N-hexamethylphosphoric triamide; tetrahydrofuran

16.1: dihydrogen peroxide; lithium hydroxide monohydrate / water; tetrahydrofuran

17.1: potassium carbonate / N,N-dimethyl-formamide

18.1: hydrogen / palladium on activated charcoal / tetrahydrofuran; methanol / 760.05 Torr

19.1: sodium hydrogencarbonate; Dess-Martin periodane / chloroform

20.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide

21.1: hydrogen bromide; acetic acid / water

With pyridine; dmap; potassium phosphate; n-butyllithium; lithium hydroxide monohydrate; 1,1,3,3-Tetramethyldisiloxane; hydrogen bromide; hydrogen; dihydrogen peroxide; iodine; diisobutylaluminium hydride; sodium hydrogencarbonate; potassium carbonate; benzotriazol-1-ol; Dess-Martin periodane; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; hydroquinone; methyl p-toluene sulfonate; triphenylphosphine; trifluoroacetic acid; lithium hexamethyldisilazane; bis-triphenylphosphine-palladium(II) chloride; palladium on activated charcoal; rhodium contaminated with carbon; (Ph₃P)2IrCl(CO); In tetrahydrofuran; methanol; N,N,N,N,N,N-hexamethylphosphoric triamide; hexane; dichloromethane; chloroform; water; N,N-dimethyl-formamide; toluene; acetonitrile;

Reference yield:

: 1342956-55-1
4-methyl-1-piperidine-1-ylpentan-1-one

: 1404377-68-9
C₂₈H₃₈N₂O₄

Guidance literature:: Multi-step reaction with 20 steps

1.1: 1,1,3,3-Tetramethyldisiloxane / (Ph₃P)2IrCl(CO) / toluene / 2 h / 20 °C

2.1: hydroquinone / acetonitrile / 95 °C

3.1: methyl p-toluene sulfonate / water / 2 h / 110 °C

3.2: 4 h / 95 °C

4.1: hydrogen / rhodium contaminated with carbon / tetrahydrofuran / 7 h / 20 °C / 760.05 Torr

5.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 20 °C

6.1: diisobutylaluminium hydride / dichloromethane / 2 h / -78 °C

6.2: Cooling with ice

7.1: triphenylphosphine / dichloromethane / 0.33 h / Cooling with ice

7.2: 0.33 h / Cooling with ice

8.1: n-butyllithium / hexane; tetrahydrofuran / -78 °C

8.2: 1 h / Cooling with ice

9.1: pyridine / methanol / 20 °C

10.1: iodine / acetonitrile / 3 h

11.1: potassium phosphate / bis-triphenylphosphine-palladium(II) chloride / N,N-dimethyl-formamide; water / 80 °C / Inert atmosphere

12.1: trifluoroacetic acid / chloroform

13.1: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / chloroform

14.1: lithium hexamethyldisilazane / N,N,N,N,N,N-hexamethylphosphoric triamide; tetrahydrofuran

15.1: dihydrogen peroxide; lithium hydroxide monohydrate / water; tetrahydrofuran

16.1: potassium carbonate / N,N-dimethyl-formamide

17.1: hydrogen / palladium on activated charcoal / tetrahydrofuran; methanol / 760.05 Torr

18.1: sodium hydrogencarbonate; Dess-Martin periodane / chloroform

19.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide

20.1: hydrogen bromide; acetic acid / water

With pyridine; dmap; potassium phosphate; n-butyllithium; lithium hydroxide monohydrate; 1,1,3,3-Tetramethyldisiloxane; hydrogen bromide; hydrogen; dihydrogen peroxide; iodine; diisobutylaluminium hydride; sodium hydrogencarbonate; potassium carbonate; benzotriazol-1-ol; Dess-Martin periodane; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; hydroquinone; methyl p-toluene sulfonate; triphenylphosphine; trifluoroacetic acid; lithium hexamethyldisilazane; bis-triphenylphosphine-palladium(II) chloride; palladium on activated charcoal; rhodium contaminated with carbon; (Ph₃P)2IrCl(CO); In tetrahydrofuran; methanol; N,N,N,N,N,N-hexamethylphosphoric triamide; hexane; dichloromethane; chloroform; water; N,N-dimethyl-formamide; toluene; acetonitrile;

Reference yield:

: 1404378-77-3
ethyl 3-isobutyl-2-piperidine-1-ylcyclobutanecarboxylate

: 1404377-68-9
C₂₈H₃₈N₂O₄

Guidance literature:: Multi-step reaction with 18 steps

1.1: methyl p-toluene sulfonate / water / 2 h / 110 °C

1.2: 4 h / 95 °C

2.1: hydrogen / rhodium contaminated with carbon / tetrahydrofuran / 7 h / 20 °C / 760.05 Torr

3.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 20 °C

4.1: diisobutylaluminium hydride / dichloromethane / 2 h / -78 °C

4.2: Cooling with ice

5.1: triphenylphosphine / dichloromethane / 0.33 h / Cooling with ice

5.2: 0.33 h / Cooling with ice

6.1: n-butyllithium / hexane; tetrahydrofuran / -78 °C

6.2: 1 h / Cooling with ice

7.1: pyridine / methanol / 20 °C

8.1: iodine / acetonitrile / 3 h

9.1: potassium phosphate / bis-triphenylphosphine-palladium(II) chloride / N,N-dimethyl-formamide; water / 80 °C / Inert atmosphere

10.1: trifluoroacetic acid / chloroform

11.1: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / chloroform

12.1: lithium hexamethyldisilazane / N,N,N,N,N,N-hexamethylphosphoric triamide; tetrahydrofuran

13.1: dihydrogen peroxide; lithium hydroxide monohydrate / water; tetrahydrofuran

14.1: potassium carbonate / N,N-dimethyl-formamide

15.1: hydrogen / palladium on activated charcoal / tetrahydrofuran; methanol / 760.05 Torr

16.1: sodium hydrogencarbonate; Dess-Martin periodane / chloroform

17.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide

18.1: hydrogen bromide; acetic acid / water

With pyridine; dmap; potassium phosphate; n-butyllithium; lithium hydroxide monohydrate; hydrogen bromide; hydrogen; dihydrogen peroxide; iodine; diisobutylaluminium hydride; sodium hydrogencarbonate; potassium carbonate; benzotriazol-1-ol; Dess-Martin periodane; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; methyl p-toluene sulfonate; triphenylphosphine; trifluoroacetic acid; lithium hexamethyldisilazane; bis-triphenylphosphine-palladium(II) chloride; palladium on activated charcoal; rhodium contaminated with carbon; In tetrahydrofuran; methanol; N,N,N,N,N,N-hexamethylphosphoric triamide; hexane; dichloromethane; chloroform; water; N,N-dimethyl-formamide; acetonitrile;