N-((1,2,3,4-tetrahydroquinolin-8-yl)methyl)-4-(trifluoromethyl)benzenesulfonamide

Base Information

• Chemical Name: N-((1,2,3,4-tetrahydroquinolin-8-yl)methyl)-4-(trifluoromethyl)benzenesulfonamide
• CAS No.: 1609646-91-4
• Molecular Formula: C₁₇H₁₇F₃N₂O₂S
• Molecular Weight: 370.395
• Mol file: 1609646-91-4.mol

Synonyms:

Chemical Property of N-((1,2,3,4-tetrahydroquinolin-8-yl)methyl)-4-(trifluoromethyl)benzenesulfonamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-((1,2,3,4-tetrahydroquinolin-8-yl)methyl)-4-(trifluoromethyl)benzenesulfonamide

There total 5 articles about N-((1,2,3,4-tetrahydroquinolin-8-yl)methyl)-4-(trifluoromethyl)benzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

N-(quinolin-8-ylmethyl)-4-(trifluoromethyl)benzenesulfonamide (1609646-64-1) → N-((1,2,3,4-tetrahydroquinolin-8-yl)methyl)-4-(trifluoromethyl)benzenesulfonamide (1609646-91-4)

Guidance literature:

With methanol; sodium tetrahydroborate; NiCl₆*H₂O; for 2h; Inert atmosphere; Schlenk technique; Cooling;

DOI:10.1021/jo5008515

Reference yield:

8-methylquinoline (611-32-5) → N-((1,2,3,4-tetrahydroquinolin-8-yl)methyl)-4-(trifluoromethyl)benzenesulfonamide (1609646-91-4)

Guidance literature:

Multi-step reaction with 2 steps

1: dichloro(pentamethylcyclopentadienyl)rhodium (III) dimer; silver hexafluoroantimonate / dichloromethane / 12 h / 100 °C / Inert atmosphere; Schlenk technique

2: sodium tetrahydroborate; NiCl₆*H₂O; methanol / 2 h / Inert atmosphere; Schlenk technique; Cooling

With methanol; sodium tetrahydroborate; silver hexafluoroantimonate; dichloro(pentamethylcyclopentadienyl)rhodium (III) dimer; NiCl₆*H₂O; In dichloromethane;

DOI:10.1021/jo5008515

Reference yield:

4-(trifluoromethyl)benzenesulfonyl azide (1152979-96-8) → N-((1,2,3,4-tetrahydroquinolin-8-yl)methyl)-4-(trifluoromethyl)benzenesulfonamide (1609646-91-4)

Guidance literature:

Multi-step reaction with 2 steps

1: dichloro(pentamethylcyclopentadienyl)rhodium (III) dimer; silver hexafluoroantimonate / dichloromethane / 12 h / 100 °C / Inert atmosphere; Schlenk technique

2: sodium tetrahydroborate; NiCl₆*H₂O; methanol / 2 h / Inert atmosphere; Schlenk technique; Cooling

With methanol; sodium tetrahydroborate; silver hexafluoroantimonate; dichloro(pentamethylcyclopentadienyl)rhodium (III) dimer; NiCl₆*H₂O; In dichloromethane;

DOI:10.1021/jo5008515

upstream raw materials:

N-(quinolin-8-ylmethyl)-4-(trifluoromethyl)benzenesulfonamide

8-methylquinoline

4-(trifluoromethyl)benzenesulfonyl azide

o-toluidine