cis-1-(2-(4-(tert-butyl)cyclohexyl)phenyl)ethanone

Base Information

• Chemical Name: cis-1-(2-(4-(tert-butyl)cyclohexyl)phenyl)ethanone
• CAS No.: 1443686-14-3
• Molecular Formula: C₁₈H₂₆O
• Molecular Weight: 258.404
• Mol file: 1443686-14-3.mol

Synonyms:

Chemical Property of cis-1-(2-(4-(tert-butyl)cyclohexyl)phenyl)ethanone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of cis-1-(2-(4-(tert-butyl)cyclohexyl)phenyl)ethanone

There total 2 articles about cis-1-(2-(4-(tert-butyl)cyclohexyl)phenyl)ethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

cis-4-tert-butylcyclohexyl chloride (13131-74-3) + (E)-4-methoxy-N-(1-phenylethylidene)benzenamine (2743-00-2,125231-22-3) → trans-1-(2-(4-(tert-butyl)cyclohexyl)phenyl)ethanone (1443686-13-2) + cis-1-(2-(4-(tert-butyl)cyclohexyl)phenyl)ethanone (1443686-14-3)

Guidance literature:

cis-4-tert-butylcyclohexyl chloride; (E)-4-methoxy-N-(1-phenylethylidene)benzenamine; With neopentylmagnesium bromide; cobalt(II) bromide; 1,3-diisopropyl-1H-benzo[d]imidazol-3-ium bromide; In tetrahydrofuran; at 0 - 20 ℃; for 24h; Schlenk technique; Inert atmosphere;

With hydrogenchloride; water; In tetrahydrofuran; Overall yield = 30 %; Inert atmosphere; Schlenk technique;

DOI:10.1021/ja403759x

Reference yield:

trans-4-tert-butyl-1-chlorocyclohexane (13145-48-7) + (E)-4-methoxy-N-(1-phenylethylidene)benzenamine (2743-00-2,125231-22-3) → trans-1-(2-(4-(tert-butyl)cyclohexyl)phenyl)ethanone (1443686-13-2) + cis-1-(2-(4-(tert-butyl)cyclohexyl)phenyl)ethanone (1443686-14-3)

Guidance literature:

trans-4-tert-butyl-1-chlorocyclohexane; (E)-4-methoxy-N-(1-phenylethylidene)benzenamine; With neopentylmagnesium bromide; cobalt(II) bromide; 1,3-diisopropyl-1H-benzo[d]imidazol-3-ium bromide; In tetrahydrofuran; at 0 - 20 ℃; for 24h; Schlenk technique; Inert atmosphere;

With hydrogenchloride; water; In tetrahydrofuran; Overall yield = 31 %; Overall yield = 23.8 mg; Inert atmosphere; Schlenk technique;

DOI:10.1021/ja403759x

upstream raw materials:

cis-4-tert-butylcyclohexyl chloride

(E)-4-methoxy-N-(1-phenylethylidene)benzenamine

trans-4-tert-butyl-1-chlorocyclohexane