5,8-Dimethoxy-1,2,3,4-tetrahydroisoquinolin-4-ol hydrochloride

Base Information

• Chemical Name: 5,8-Dimethoxy-1,2,3,4-tetrahydroisoquinolin-4-ol hydrochloride
• CAS No.: 102073-77-8
• Molecular Formula: C₁₁H₁₅NO₃
• Molecular Weight: 209.245
• Hs Code.: 2933499090
• DSSTox Substance ID: DTXSID90585831
• Mol file: 102073-77-8.mol

Synonyms:5,8-dimethoxy-1,2,3,4-tetrahydroisoquinolin-4-ol hydrochloride;102073-77-8;1052540-04-1;5,8-dimethoxy-1,2,3,4-tetrahydroisoquinolin-4-ol;hydrochloride;DTXSID90585831;CEA07377;AKOS009028753;CS-0234704;EN300-14604;5,8-DIMETHOXY-1,2,3,4-TETRAHYDRO-4-ISOQUINOLINOL HYDROCHLORIDE;5,8-Dimethoxy-1,2,3,4-tetrahydroisoquinolin-4-ol--hydrogen chloride (1/1)

Chemical Property of 5,8-Dimethoxy-1,2,3,4-tetrahydroisoquinolin-4-ol hydrochloride

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Boiling Point: 395.3°Cat760mmHg
• Flash Point: 192.9°C
• PSA: 50.72000
• Density: g/cm³
• LogP: 1.97120
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 2
• Exact Mass: 245.0818711
• Heavy Atom Count: 16
• Complexity: 212

Purity/Quality:

98%Min ^*data from raw suppliers

5,8-Dimethoxy-1,2,3,4-tetrahydroisoquinolin-4-olHydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=C2CNCC(C2=C(C=C1)OC)O.Cl

Technology Process of 5,8-Dimethoxy-1,2,3,4-tetrahydroisoquinolin-4-ol hydrochloride

There total 3 articles about 5,8-Dimethoxy-1,2,3,4-tetrahydroisoquinolin-4-ol hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

acetaldehyde dimethyl acetal (54879-79-7) → 4-hydroxy-5,8-dimethoxy-1,2,3,4-tetrahydroisoquinoline (102073-77-8)

Guidance literature:

With hydrogenchloride; at 40 - 42 ℃; for 30h;

DOI:10.1021/jm00157a027

Reference yield:

acetaldehyde dimethyl acetal (54879-66-2) → 4-hydroxy-5,8-dimethoxy-1,2,3,4-tetrahydroisoquinoline (102073-77-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 99.9 percent / sodium borohydride / ethanol / 20 h / Ambient temperature

2: 95 percent / 6 N HCl / 30 h / 40 - 42 °C

With hydrogenchloride; sodium tetrahydroborate; In ethanol;

DOI:10.1021/jm00157a027

Reference yield:

2,5-dimethoxybenzaldehyde (93-02-7) → 4-hydroxy-5,8-dimethoxy-1,2,3,4-tetrahydroisoquinoline (102073-77-8)

Guidance literature:

Multi-step reaction with 3 steps

1: 100 percent / toluene / 4 h / Heating

2: 99.9 percent / sodium borohydride / ethanol / 20 h / Ambient temperature

3: 95 percent / 6 N HCl / 30 h / 40 - 42 °C

With hydrogenchloride; sodium tetrahydroborate; In ethanol; toluene;

DOI:10.1021/jm00157a027

upstream raw materials:

acetaldehyde dimethyl acetal

acetaldehyde dimethyl acetal

2,5-dimethoxybenzaldehyde