C₂₀H₁₉Cl₂F₃N₄O₃

Base Information

• Chemical Name: C₂₀H₁₉Cl₂F₃N₄O₃
• CAS No.: 1427300-74-0
• Molecular Formula: C₂₀H₁₉Cl₂F₃N₄O₃
• Molecular Weight: 491.297
• Mol file: 1427300-74-0.mol

Synonyms:

Chemical Property of C₂₀H₁₉Cl₂F₃N₄O₃

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₂₀H₁₉Cl₂F₃N₄O₃

There total 2 articles about C₂₀H₁₉Cl₂F₃N₄O₃ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C20H18Cl2F3N3O4 → C20H19Cl2F3N4O3 (1427300-74-0)

Guidance literature:

With ammonium chloride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In dichloromethane;

DOI:10.1016/j.bmcl.2013.01.064

Reference yield:

C21H20Cl2F3N3O4 (1431138-78-1) → C20H19Cl2F3N4O3 (1427300-74-0)

Guidance literature:

Multi-step reaction with 2 steps

1: lithium hydroxide / tetrahydrofuran

2: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol; triethylamine; ammonium chloride / dichloromethane

With ammonium chloride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; lithium hydroxide; In tetrahydrofuran; dichloromethane;

DOI:10.1016/j.bmcl.2013.01.064

Reference yield:

C20H19Cl2F3N4O3 (1427300-74-0) → C21H13Cl3F3N7 (1427301-08-3)

Guidance literature:

Multi-step reaction with 3 steps

1: 20 °C

2: acetic acid / 2 h / 60 °C

3: trifluoroacetic acid / dichloromethane

With acetic acid; trifluoroacetic acid; In dichloromethane;

DOI:10.1016/j.bmcl.2013.01.064

upstream raw materials:

C₂₁H₂₀Cl₂F₃N₃O₄

Downstream raw materials:

C₂₇H₂₄Cl₂F₃N₇O₂

C₂₇H₂₄Cl₂F₃N₇O₂

C₂₇H₂₄Cl₂F₃N₇O₃

C₂₈H₂₆Cl₂F₃N₇O₃