Technology Process of [2-methyl-4-(p-tolyl)-5,6,7,8-tetrahydro-9-thia-1,7-diaza-fluoren-3-yl]pentanoate ammonium salt
There total 4 articles about [2-methyl-4-(p-tolyl)-5,6,7,8-tetrahydro-9-thia-1,7-diaza-fluoren-3-yl]pentanoate ammonium salt which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: pyridinium p-toluenesulfonate / water; toluene / Dean-stark trap; Reflux
2.1: lithium diisopropyl amide / tetrahydrofuran / 0.5 h / -78 °C
2.2: 5.5 h / 20 °C
3.1: boron tribromide / hexane; dichloromethane / -78 - -20 °C / Inert atmosphere
4.1: chloro-trimethyl-silane / N,N-dimethyl-formamide / 48 h / 100 °C / Inert atmosphere; Sealed tube
5.1: sodium hydroxide / methanol; ethanol / 18 h / 90 °C
5.2: pH 2
With
chloro-trimethyl-silane; boron tribromide; sodium hydroxide; lithium diisopropyl amide;
pyridinium p-toluenesulfonate;
In
tetrahydrofuran; methanol; ethanol; hexane; dichloromethane; water; N,N-dimethyl-formamide; toluene;
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: boron tribromide / hexane; dichloromethane / -78 - -20 °C / Inert atmosphere
2.1: chloro-trimethyl-silane / N,N-dimethyl-formamide / 48 h / 100 °C / Inert atmosphere; Sealed tube
3.1: sodium hydroxide / methanol; ethanol / 18 h / 90 °C
3.2: pH 2
With
chloro-trimethyl-silane; boron tribromide; sodium hydroxide;
In
methanol; ethanol; hexane; dichloromethane; N,N-dimethyl-formamide;
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: lithium diisopropyl amide / tetrahydrofuran / 0.5 h / -78 °C
1.2: 5.5 h / 20 °C
2.1: boron tribromide / hexane; dichloromethane / -78 - -20 °C / Inert atmosphere
3.1: chloro-trimethyl-silane / N,N-dimethyl-formamide / 48 h / 100 °C / Inert atmosphere; Sealed tube
4.1: sodium hydroxide / methanol; ethanol / 18 h / 90 °C
4.2: pH 2
With
chloro-trimethyl-silane; boron tribromide; sodium hydroxide; lithium diisopropyl amide;
In
tetrahydrofuran; methanol; ethanol; hexane; dichloromethane; N,N-dimethyl-formamide;
