cis-1-Benzylhexahydrocyclopenta[b]pyrrol-6(1H)-one

Base Information

Chemical Name:cis-1-Benzylhexahydrocyclopenta[b]pyrrol-6(1H)-one
CAS No.:188057-86-5
Molecular Formula:C₁₄H₁₇NO
Molecular Weight:215.295
Hs Code.:
DSSTox Substance ID:DTXSID901168410
Nikkaji Number:J1.761.670F

Synonyms:cis-1-Benzylhexahydrocyclopenta[b]pyrrol-6(1H)-one;122718-97-2;SCHEMBL5937718;MDHHQXUKNXLARZ-OCCSQVGLSA-N;DTXSID901168410;188057-86-5;(3aR,6aS)-Hexahydro-1-(phenylmethyl)cyclopenta[b]pyrrol-6(1H)-one

Suppliers and Price of cis-1-Benzylhexahydrocyclopenta[b]pyrrol-6(1H)-one

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Total 0 raw suppliers

Chemical Property of cis-1-Benzylhexahydrocyclopenta[b]pyrrol-6(1H)-one

Chemical Property:

XLogP3:2.1
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:2
Exact Mass:215.131014166
Heavy Atom Count:16
Complexity:270

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:C1CC(=O)C2C1CCN2CC3=CC=CC=C3
Isomeric SMILES:C1CC(=O)[C@@H]2[C@H]1CCN2CC3=CC=CC=C3

Technology Process of cis-1-Benzylhexahydrocyclopenta[b]pyrrol-6(1H)-one

There total 8 articles about cis-1-Benzylhexahydrocyclopenta[b]pyrrol-6(1H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 13668-61-6
(cyclopent-2-eneyl)acetic acid

: 188057-86-5
(3aR,6aS)-1-Benzyl-hexahydro-cyclopenta[b]pyrrol-6-one

Guidance literature:: Multi-step reaction with 8 steps

1: (COCl)2, dimethylformamide / CH₂Cl₂ / 3 h / 23 °C

2: triethylamine / tetrahydrofuran / 0.5 h / 23 °C

3: 93 percent / lithium aluminium hydride / tetrahydrofuran / 4 h / Heating

4: N-bromosuccinimide / diethyl ether / 1 h / 0 °C

5: cuprous bromide / CH₂Cl₂ / 2 h / 0 °C

6: 83 percent / lithium hydroxide/dimethoxyethane / H₂O / 1 h / Heating

With lithium hydroxide; N-Bromosuccinimide; lithium aluminium tetrahydride; 1,2-dimethoxyethane; oxalyl dichloride; triethylamine; N,N-dimethyl-formamide; copper(I) bromide; In tetrahydrofuran; diethyl ether; dichloromethane; water;
DOI:10.1016/S0040-4039(01)93796-7

Reference yield:

: 933-03-9
2-(cyclopent-2-en-1-yl)acetyl chloride

: 188057-86-5
(3aR,6aS)-1-Benzyl-hexahydro-cyclopenta[b]pyrrol-6-one

Guidance literature:: Multi-step reaction with 7 steps

1: triethylamine / tetrahydrofuran / 0.5 h / 23 °C

2: 93 percent / lithium aluminium hydride / tetrahydrofuran / 4 h / Heating

3: N-bromosuccinimide / diethyl ether / 1 h / 0 °C

4: cuprous bromide / CH₂Cl₂ / 2 h / 0 °C

5: 83 percent / lithium hydroxide/dimethoxyethane / H₂O / 1 h / Heating

With lithium hydroxide; N-Bromosuccinimide; lithium aluminium tetrahydride; 1,2-dimethoxyethane; triethylamine; copper(I) bromide; In tetrahydrofuran; diethyl ether; dichloromethane; water;
DOI:10.1016/S0040-4039(01)93796-7

Reference yield:

: 92250-02-7
N-benzyl-2'-cyclopentenylacetamide

: 188057-86-5
(3aR,6aS)-1-Benzyl-hexahydro-cyclopenta[b]pyrrol-6-one

Guidance literature:: Multi-step reaction with 6 steps

1: 93 percent / lithium aluminium hydride / tetrahydrofuran / 4 h / Heating

2: N-bromosuccinimide / diethyl ether / 1 h / 0 °C

3: cuprous bromide / CH₂Cl₂ / 2 h / 0 °C

4: 83 percent / lithium hydroxide/dimethoxyethane / H₂O / 1 h / Heating

With lithium hydroxide; N-Bromosuccinimide; lithium aluminium tetrahydride; 1,2-dimethoxyethane; copper(I) bromide; In tetrahydrofuran; diethyl ether; dichloromethane; water;
DOI:10.1016/S0040-4039(01)93796-7