Technology Process of 1-bromo-2,4-difluoro3-iodobenzene
There total 1 articles about 1-bromo-2,4-difluoro3-iodobenzene which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
2,4-difluorobromobenzene;
With
lithium diisopropyl amide;
In
tetrahydrofuran; n-heptane; ethylbenzene;
at -78 ℃;
for 1h;
Schlenk technique;
Inert atmosphere;
Glovebox;
With
iodine;
In
tetrahydrofuran; n-heptane; ethylbenzene;
at -78 ℃;
for 1h;
Schlenk technique;
Inert atmosphere;
Glovebox;
DOI:10.1016/j.jorganchem.2018.06.010
- Guidance literature:
-
Multi-step reaction with 2 steps
1: tetrakis(triphenylphosphine) palladium(0); copper(l) iodide; diisopropylamine / 20 °C / Schlenk technique; Inert atmosphere; Glovebox
2: potassium carbonate / tetrahydrofuran; methanol / 3 h / 20 °C / Schlenk technique; Inert atmosphere; Glovebox
With
copper(l) iodide; tetrakis(triphenylphosphine) palladium(0); potassium carbonate; diisopropylamine;
In
tetrahydrofuran; methanol;
DOI:10.1016/j.jorganchem.2018.06.010
- Guidance literature:
-
Multi-step reaction with 3 steps
1: tetrakis(triphenylphosphine) palladium(0); copper(l) iodide; diisopropylamine / 20 °C / Schlenk technique; Inert atmosphere; Glovebox
2: potassium carbonate / tetrahydrofuran; methanol / 3 h / 20 °C / Schlenk technique; Inert atmosphere; Glovebox
3: diethyl sulphide / toluene / 72 h / 110 °C / Inert atmosphere; Schlenk technique; Glovebox
With
copper(l) iodide; tetrakis(triphenylphosphine) palladium(0); diethyl sulphide; potassium carbonate; diisopropylamine;
In
tetrahydrofuran; methanol; toluene;
DOI:10.1016/j.jorganchem.2018.06.010
