Technology Process of 2-benzyloxycarbonylacetyl-7,12,18-triethyl-3,8,13,17-tetramethylporphyrin
There total 8 articles about 2-benzyloxycarbonylacetyl-7,12,18-triethyl-3,8,13,17-tetramethylporphyrin which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 7 steps
1: 6 g / hydrochloric acid / ethanol / 2 h / Heating
2: 1.) sodium hydroxide, 2.) acetic acid / 1.) ethanol, 3.5 h, 2.) ethanol, water, 0 deg C, 1 h
3: 2.) benzoyl chloride / 1.) reflux, 30 min, 2.) from 0 deg C to RT
4: 245 mg / trifluoroacetic acid / methanol / 1.) 0 deg C, 20 min, 2.) heating, overnight
5: 227 mg / pyridine, potassium hydroxide / methanol / 3 h / Heating
6: oxalyl chloride / CH2Cl2 / 0.42 h / Heating
7: 1.) isopropylmagnesium bromide / 1.) tetrahydrofuran, reflux, 5 min, 2.) 5 min
With
pyridine; hydrogenchloride; potassium hydroxide; sodium hydroxide; oxalyl dichloride; isopropylmagnesium bromide; benzoyl chloride; acetic acid; trifluoroacetic acid;
In
methanol; ethanol; dichloromethane;
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 2.) benzoyl chloride / 1.) reflux, 30 min, 2.) from 0 deg C to RT
2: 245 mg / trifluoroacetic acid / methanol / 1.) 0 deg C, 20 min, 2.) heating, overnight
3: 227 mg / pyridine, potassium hydroxide / methanol / 3 h / Heating
4: oxalyl chloride / CH2Cl2 / 0.42 h / Heating
5: 1.) isopropylmagnesium bromide / 1.) tetrahydrofuran, reflux, 5 min, 2.) 5 min
With
pyridine; potassium hydroxide; oxalyl dichloride; isopropylmagnesium bromide; benzoyl chloride; trifluoroacetic acid;
In
methanol; dichloromethane;
- Guidance literature:
-
Multi-step reaction with 6 steps
1: 1.) sodium hydroxide, 2.) acetic acid / 1.) ethanol, 3.5 h, 2.) ethanol, water, 0 deg C, 1 h
2: 2.) benzoyl chloride / 1.) reflux, 30 min, 2.) from 0 deg C to RT
3: 245 mg / trifluoroacetic acid / methanol / 1.) 0 deg C, 20 min, 2.) heating, overnight
4: 227 mg / pyridine, potassium hydroxide / methanol / 3 h / Heating
5: oxalyl chloride / CH2Cl2 / 0.42 h / Heating
6: 1.) isopropylmagnesium bromide / 1.) tetrahydrofuran, reflux, 5 min, 2.) 5 min
With
pyridine; potassium hydroxide; sodium hydroxide; oxalyl dichloride; isopropylmagnesium bromide; benzoyl chloride; acetic acid; trifluoroacetic acid;
In
methanol; dichloromethane;
